243938

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2208752..2209338 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag M1775_RS10335 Protein ID WP_003410010.1
Coordinates 2208752..2209096 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag M1775_RS10340 Protein ID WP_003410014.1
Coordinates 2209090..2209338 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS10300 (M1775_10305) 2204456..2205055 + 600 WP_003409989.1 L-lysine exporter -
M1775_RS10305 (M1775_10310) 2205471..2205899 + 429 WP_003409992.1 cellulose-binding protein -
M1775_RS10310 (M1775_10315) 2206125..2206664 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1775_RS10315 (M1775_10320) 2207184..2207744 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
M1775_RS10320 (M1775_10325) 2207741..2208082 - 342 WP_003410003.1 DUF2384 domain-containing protein -
M1775_RS10325 (M1775_10330) 2208168..2208425 + 258 WP_003410006.1 hypothetical protein -
M1775_RS10330 (M1775_10335) 2208326..2208661 - 336 WP_003410009.1 dehydrogenase -
M1775_RS10335 (M1775_10340) 2208752..2209096 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
M1775_RS10340 (M1775_10345) 2209090..2209338 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
M1775_RS10345 (M1775_10350) 2209438..2211753 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M1775_RS10350 (M1775_10355) 2211750..2212022 - 273 WP_003410017.1 DUF1490 family protein -
M1775_RS10355 (M1775_10360) 2212075..2212431 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
M1775_RS10360 (M1775_10365) 2212588..2213355 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T243938 WP_003410010.1 NZ_CP096846:c2209096-2208752 [Mycobacterium tuberculosis variant bovis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT243938 WP_003410014.1 NZ_CP096846:c2209338-2209090 [Mycobacterium tuberculosis variant bovis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References