243937

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2207184..2208082 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag M1775_RS10315 Protein ID WP_003410001.1
Coordinates 2207184..2207744 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag M1775_RS10320 Protein ID WP_003410003.1
Coordinates 2207741..2208082 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS10285 (M1775_10290) 2202353..2203006 - 654 WP_003409976.1 cutinase Cfp21 -
M1775_RS10290 (M1775_10295) 2203121..2203351 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1775_RS10295 (M1775_10300) 2203436..2204347 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1775_RS10300 (M1775_10305) 2204456..2205055 + 600 WP_003409989.1 L-lysine exporter -
M1775_RS10305 (M1775_10310) 2205471..2205899 + 429 WP_003409992.1 cellulose-binding protein -
M1775_RS10310 (M1775_10315) 2206125..2206664 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1775_RS10315 (M1775_10320) 2207184..2207744 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
M1775_RS10320 (M1775_10325) 2207741..2208082 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
M1775_RS10325 (M1775_10330) 2208168..2208425 + 258 WP_003410006.1 hypothetical protein -
M1775_RS10330 (M1775_10335) 2208326..2208661 - 336 WP_003410009.1 dehydrogenase -
M1775_RS10335 (M1775_10340) 2208752..2209096 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
M1775_RS10340 (M1775_10345) 2209090..2209338 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
M1775_RS10345 (M1775_10350) 2209438..2211753 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M1775_RS10350 (M1775_10355) 2211750..2212022 - 273 WP_003410017.1 DUF1490 family protein -
M1775_RS10355 (M1775_10360) 2212075..2212431 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T243937 WP_003410001.1 NZ_CP096846:c2207744-2207184 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT243937 WP_003410003.1 NZ_CP096846:c2208082-2207741 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAE4

References