243936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2199858..2200546 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag M1775_RS10270 Protein ID WP_003409958.1
Coordinates 2199858..2200277 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag M1775_RS10275 Protein ID WP_003409968.1
Coordinates 2200286..2200546 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS10240 (M1775_10245) 2194864..2195169 + 306 Protein_2023 ABC transporter permease -
M1775_RS10245 (M1775_10250) 2195165..2195245 + 81 Protein_2024 hypothetical protein -
M1775_RS10250 (M1775_10255) 2195353..2196201 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
M1775_RS10255 (M1775_10260) 2196164..2197609 - 1446 WP_003409946.1 APC family permease -
M1775_RS10260 (M1775_10265) 2197788..2198474 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
M1775_RS10265 (M1775_10270) 2198665..2199633 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
M1775_RS10270 (M1775_10275) 2199858..2200277 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS10275 (M1775_10280) 2200286..2200546 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1775_RS10280 (M1775_10285) 2200689..2202365 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
M1775_RS10285 (M1775_10290) 2202353..2203006 - 654 WP_003409976.1 cutinase Cfp21 -
M1775_RS10290 (M1775_10295) 2203121..2203351 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1775_RS10295 (M1775_10300) 2203436..2204347 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1775_RS10300 (M1775_10305) 2204456..2205055 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T243936 WP_003409958.1 NZ_CP096846:c2200277-2199858 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT243936 WP_003409968.1 NZ_CP096846:c2200546-2200286 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References