243933

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2181808..2182511 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag M1775_RS10120 Protein ID WP_003409778.1
Coordinates 2181808..2182137 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag M1775_RS10125 Protein ID WP_003409780.1
Coordinates 2182134..2182511 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS10100 (M1775_10105) 2178191..2179261 + 1071 WP_003899091.1 epoxide hydrolase EphB -
M1775_RS10105 (M1775_10110) 2179258..2179773 + 516 WP_273585947.1 flavin reductase family protein -
M1775_RS10110 (M1775_10115) 2179770..2180831 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
M1775_RS10115 (M1775_10120) 2180828..2181598 + 771 WP_003409775.1 SDR family oxidoreductase -
M1775_RS10120 (M1775_10125) 2181808..2182137 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M1775_RS10125 (M1775_10130) 2182134..2182511 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
M1775_RS10130 (M1775_10135) 2182508..2183098 - 591 WP_003910477.1 SEC-C metal-binding domain-containing protein -
M1775_RS10135 (M1775_10140) 2183153..2184517 + 1365 WP_003899094.1 HNH endonuclease signature motif containing protein -
M1775_RS10140 (M1775_10145) 2184672..2185124 - 453 WP_010950636.1 lipoprotein -
M1775_RS10145 (M1775_10150) 2185188..2185589 + 402 WP_003409869.1 hypothetical protein -
M1775_RS10150 (M1775_10155) 2185582..2185764 - 183 WP_003409870.1 hypothetical protein -
M1775_RS10155 (M1775_10160) 2185878..2186228 - 351 WP_003409871.1 hypothetical protein -
M1775_RS10160 (M1775_10165) 2186239..2187141 - 903 WP_003409874.1 hypothetical protein -
M1775_RS10165 (M1775_10170) 2187162..2187353 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T243933 WP_003409778.1 NZ_CP096846:c2182137-2181808 [Mycobacterium tuberculosis variant bovis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT243933 WP_003409780.1 NZ_CP096846:c2182511-2182134 [Mycobacterium tuberculosis variant bovis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References