243932

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1948947..1949407 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag M1775_RS09100 Protein ID WP_003408531.1
Coordinates 1949159..1949407 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag M1775_RS09095 Protein ID WP_003408528.1
Coordinates 1948947..1949159 (+) Length 71 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS09080 (M1775_09085) 1945425..1946612 - 1188 WP_003898992.1 nitrate transporter NarK -
M1775_RS09085 (M1775_09090) 1946899..1947183 + 285 WP_003408522.1 DUF1876 domain-containing protein -
M1775_RS09090 (M1775_09095) 1947197..1948879 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
M1775_RS09095 (M1775_09100) 1948947..1949159 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1775_RS09100 (M1775_09105) 1949159..1949407 + 249 WP_003408531.1 hypothetical protein Toxin
M1775_RS09105 (M1775_09110) 1949415..1950153 + 739 Protein_1796 hypothetical protein -
M1775_RS09110 (M1775_09115) 1950247..1951947 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
M1775_RS09115 (M1775_09120) 1952232..1952633 - 402 WP_010950586.1 hypothetical protein -
M1775_RS09120 (M1775_09125) 1952623..1953234 - 612 Protein_1799 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(2-69)


Sequences


Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T243932 WP_003408531.1 NZ_CP096846:1949159-1949407 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp


Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT243932 WP_003408528.1 NZ_CP096846:1948947-1949159 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26


Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References