Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1389969..1390528 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag M1775_RS06650 Protein ID WP_003898789.1
Coordinates 1389969..1390262 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag M1775_RS06655 Protein ID WP_003406322.1
Coordinates 1390259..1390528 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS06625 (M1775_06620) 1385564..1385824 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
M1775_RS06630 (M1775_06625) 1385821..1386252 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
M1775_RS06635 (M1775_06630) 1386275..1387961 - 1687 Protein_1309 PE family protein -
M1775_RS06640 (M1775_06635) 1388141..1389001 + 861 WP_003406306.1 glycine betaine ABC transporter substrate-binding protein -
M1775_RS06645 (M1775_06640) 1389082..1389912 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
M1775_RS06650 (M1775_06645) 1389969..1390262 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
M1775_RS06655 (M1775_06650) 1390259..1390528 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1775_RS06660 (M1775_06655) 1390641..1394336 - 3696 WP_010950509.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
M1775_RS06665 (M1775_06660) 1394478..1395266 - 789 WP_010950510.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T243926 WP_003898789.1 NZ_CP096846:c1390262-1389969 [Mycobacterium tuberculosis variant bovis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT243926 WP_003406322.1 NZ_CP096846:c1390528-1390259 [Mycobacterium tuberculosis variant bovis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References