243918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 756671..757359 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag M1775_RS03505 Protein ID WP_003403386.1
Coordinates 756671..757108 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag M1775_RS03510 Protein ID WP_003911263.1
Coordinates 757105..757359 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS03475 (M1775_03475) 752922..753932 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
M1775_RS03480 (M1775_03480) 754320..754703 - 384 WP_003403365.1 ribonuclease VapC6 -
M1775_RS03485 (M1775_03485) 754798..754953 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
M1775_RS03490 (M1775_03490) 755029..755745 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
M1775_RS03495 (M1775_03495) 756021..756329 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
M1775_RS03500 (M1775_03500) 756316..756561 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
M1775_RS03505 (M1775_03505) 756671..757108 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS03510 (M1775_03510) 757105..757359 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
M1775_RS03515 (M1775_03515) 757473..759836 + 2364 WP_003403397.1 arylsulfatase AtsD -
M1775_RS03520 (M1775_03520) 759899..760225 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M1775_RS03525 (M1775_03525) 760137..760475 + 339 WP_003403405.1 PIN domain-containing protein -
M1775_RS03530 (M1775_03530) 760472..760645 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T243918 WP_003403386.1 NZ_CP096846:c757108-756671 [Mycobacterium tuberculosis variant bovis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT243918 WP_003911263.1 NZ_CP096846:c757359-757105 [Mycobacterium tuberculosis variant bovis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References