Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 756021..756561 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag M1775_RS03495 Protein ID WP_003403376.1
Coordinates 756021..756329 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag M1775_RS03500 Protein ID WP_003403381.1
Coordinates 756316..756561 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS03470 (M1775_03470) 751336..752841 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
M1775_RS03475 (M1775_03475) 752922..753932 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
M1775_RS03480 (M1775_03480) 754320..754703 - 384 WP_003403365.1 ribonuclease VapC6 -
M1775_RS03485 (M1775_03485) 754798..754953 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
M1775_RS03490 (M1775_03490) 755029..755745 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
M1775_RS03495 (M1775_03495) 756021..756329 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M1775_RS03500 (M1775_03500) 756316..756561 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
M1775_RS03505 (M1775_03505) 756671..757108 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
M1775_RS03510 (M1775_03510) 757105..757359 - 255 WP_003911263.1 antitoxin VapB7 -
M1775_RS03515 (M1775_03515) 757473..759836 + 2364 WP_003403397.1 arylsulfatase AtsD -
M1775_RS03520 (M1775_03520) 759899..760225 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M1775_RS03525 (M1775_03525) 760137..760475 + 339 WP_003403405.1 PIN domain-containing protein -
M1775_RS03530 (M1775_03530) 760472..760645 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T243916 WP_003403376.1 NZ_CP096846:c756329-756021 [Mycobacterium tuberculosis variant bovis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T243916 UFRD01000002:c2869913-2869626 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT243916 WP_003403381.1 NZ_CP096846:c756561-756316 [Mycobacterium tuberculosis variant bovis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT243916 UFRD01000002:c2869639-2869337 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References