243912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 711594..712219 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag M1775_RS03260 Protein ID WP_003403218.1
Coordinates 711818..712219 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag M1775_RS03255 Protein ID WP_003403213.1
Coordinates 711594..711821 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS03230 (M1775_03230) 706773..706994 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M1775_RS03235 (M1775_03235) 707136..707741 + 606 WP_003898526.1 hypothetical protein -
M1775_RS03240 (M1775_03240) 707760..710327 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
M1775_RS03245 (M1775_03245) 710411..711160 + 750 WP_003898528.1 hypothetical protein -
M1775_RS03250 (M1775_03250) 711157..711399 + 243 WP_003403210.1 hypothetical protein -
M1775_RS03255 (M1775_03255) 711594..711821 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
M1775_RS03260 (M1775_03260) 711818..712219 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
M1775_RS03265 (M1775_03265) 712348..712431 + 84 Protein_647 galactose-1-phosphate uridylyltransferase -
M1775_RS03270 (M1775_03270) 712450..713532 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1775_RS03275 (M1775_03275) 713529..714620 + 1092 WP_003403225.1 galactokinase -
M1775_RS03280 (M1775_03280) 715015..716172 + 1158 WP_003903091.1 hypothetical protein -
M1775_RS03285 (M1775_03285) 716183..717130 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T243912 WP_003403218.1 NZ_CP096846:711818-712219 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T243912 NZ_OY019090:87864-88145 [Escherichia coli O25b:H4-ST131]
ATGACTTATGAACTGGAATTTGAGCGCAGGGCCCTGAAAGAATGGCATAAGCTCGGTCATACAGTCCGTGAGCAGTTCAA
AAAGAAACTGTCAGAACGCCTGAAAAATCCAAGGGTCCCTGCTGCCAGGCTACATGGTCATACTGACCGTTATAAAATCA
AGCTTCGTGCATCTGGTTACAGGCTCGTCTATCAGGTGATTGATGAGAAAATTGTTTTGCTCGTTATTGCTGTAGGAAAA
AGGGAAAGCAGTGAGGTCTACCAGATGGCTGATATTCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT243912 WP_003403213.1 NZ_CP096846:711594-711821 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT243912 NZ_OY019090:87623-87874 [Escherichia coli O25b:H4-ST131]
ATGAGTTACCAGATTTTGACCACGACAGCAGCAAGTATTACTGAGCTGAAAAAAAATCCTATGGGCACGGTAGCCGAAGG
TGAAGGAGGGGCCGTTGCAATCCTGAACCGAAATGAGCCTGCGTTCTACTGTGTCCCTCCGGAACTTTATGCCTACTACC
GGGAGCTCGCCGAAGATGCTGAGCTAAACGCAATTGCTGATGAAAGAATGAAGAATCCGGACATTGTGAAGGTTAGTCTG
GATGACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References