Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 678519..679138 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag M1775_RS03075 Protein ID WP_003403047.1
Coordinates 678731..679138 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag M1775_RS03070 Protein ID WP_003403039.1
Coordinates 678519..678734 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS03060 (M1775_03060) 677047..677805 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
M1775_RS03065 (M1775_03065) 677934..678425 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
M1775_RS03070 (M1775_03070) 678519..678734 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
M1775_RS03075 (M1775_03075) 678731..679138 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
M1775_RS03080 (M1775_03080) 679198..679884 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
M1775_RS03085 (M1775_03085) 680038..682671 + 2634 WP_273586035.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T243908 WP_003403047.1 NZ_CP096846:678731-679138 [Mycobacterium tuberculosis variant bovis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T243908 NZ_OY019089:c94432-94283 [Escherichia coli O25b:H4-ST131]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT243908 WP_003403039.1 NZ_CP096846:678519-678734 [Mycobacterium tuberculosis variant bovis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT243908 NZ_OY019089:94476-94537 [Escherichia coli O25b:H4-ST131]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References