Detailed information of TA system TA243902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3771677..3772362
• Replicon: chromosome
• Accession: NZ_CP096845
• Organism: Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: M1777_RS17765
• Protein ID: WP_003417998.1
• Coordinates: 3771952..3772362 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: M1777_RS17760
• Protein ID: WP_003912220.1
• Coordinates: 3771677..3771955 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1777_RS17740 (M1777_17750)	3767666..3769267	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
M1777_RS17745 (M1777_17755)	3769284..3769988	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
M1777_RS17750 (M1777_17760)	3770106..3770672	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
M1777_RS17755 (M1777_17765)	3770734..3771621	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
M1777_RS17760 (M1777_17770)	3771677..3771955	+	279	WP_003912220.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1777_RS17765 (M1777_17775)	3771952..3772362	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
M1777_RS17770 (M1777_17780)	3772395..3774131	-	1737	WP_003418002.1	cholesterol oxidase	-
M1777_RS17775 (M1777_17785)	3774187..3775314	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
M1777_RS17780 (M1777_17790)	3775334..3776923	-	1590	WP_003900682.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T243902 WP_003417998.1 NZ_CP096845:3771952-3772362 [Mycobacterium tuberculosis variant bovis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T243902 NZ_OY019088:3569989-3570366 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10280.75 Da
• Isoelectric Point: 10.1819

>AT243902 WP_003912220.1 NZ_CP096845:3771677-3771955 [Mycobacterium tuberculosis variant bovis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT243902 NZ_OY019088:3569531-3569899 [Escherichia coli O25b:H4-ST131]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: G0TIR9