Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3131336..3132023 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag M1777_RS14955 Protein ID WP_003414624.1
Coordinates 3131580..3132023 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag M1777_RS14950 Protein ID WP_003414620.1
Coordinates 3131336..3131593 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS14930 (M1777_14940) 3126656..3127510 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
M1777_RS14935 (M1777_14945) 3127566..3128729 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
M1777_RS14940 (M1777_14950) 3128746..3129960 - 1215 WP_011799297.1 zinc metalloprotease Rip -
M1777_RS14945 (M1777_14955) 3129968..3131209 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
M1777_RS14950 (M1777_14960) 3131336..3131593 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
M1777_RS14955 (M1777_14965) 3131580..3132023 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
M1777_RS14960 (M1777_14970) 3132103..3132765 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
M1777_RS14965 (M1777_14975) 3132861..3133052 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
M1777_RS14970 (M1777_14980) 3133384..3135132 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
M1777_RS14975 (M1777_14985) 3135228..3135809 + 582 WP_003414644.1 fasciclin domain-containing protein -
M1777_RS14980 (M1777_14990) 3135909..3136175 + 267 WP_031657293.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T243897 WP_003414624.1 NZ_CP096845:3131580-3132023 [Mycobacterium tuberculosis variant bovis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T243897 NZ_OY019088:c2533508-2533401 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT243897 WP_003414620.1 NZ_CP096845:3131336-3131593 [Mycobacterium tuberculosis variant bovis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT243897 NZ_OY019088:2533557-2533622 [Escherichia coli O25b:H4-ST131]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References