Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2888856..2889570 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag M1777_RS13600 Protein ID WP_003413460.1
Coordinates 2889130..2889570 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag M1777_RS13595 Protein ID WP_003413456.1
Coordinates 2888856..2889143 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS13560 (M1777_13570) 2884278..2884523 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
M1777_RS13565 (M1777_13575) 2884520..2884924 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
M1777_RS13570 (M1777_13580) 2885141..2885761 + 621 WP_003413441.1 DUF4178 domain-containing protein -
M1777_RS13575 (M1777_13585) 2885772..2886266 + 495 WP_003413444.1 DUF2617 family protein -
M1777_RS13580 (M1777_13590) 2886263..2886694 + 432 WP_003413445.1 DUF4247 domain-containing protein -
M1777_RS13585 (M1777_13595) 2886719..2887177 + 459 WP_003413451.1 DUF350 domain-containing protein -
M1777_RS13590 (M1777_13600) 2887174..2888745 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
M1777_RS13595 (M1777_13605) 2888856..2889143 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
M1777_RS13600 (M1777_13610) 2889130..2889570 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
M1777_RS13605 (M1777_13615) 2889591..2890346 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
M1777_RS13610 (M1777_13620) 2890479..2891075 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
M1777_RS13615 (M1777_13625) 2891083..2891928 - 846 WP_010950749.1 acyl-CoA thioesterase II -
M1777_RS13620 (M1777_13630) 2891957..2892856 - 900 WP_273585836.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
M1777_RS13625 (M1777_13635) 2892984..2893658 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T243891 WP_003413460.1 NZ_CP096845:2889130-2889570 [Mycobacterium tuberculosis variant bovis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T243891 NZ_OY019088:c1767199-1766792 [Escherichia coli O25b:H4-ST131]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT243891 WP_003413456.1 NZ_CP096845:2888856-2889143 [Mycobacterium tuberculosis variant bovis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT243891 NZ_OY019088:c1767446-1767180 [Escherichia coli O25b:H4-ST131]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References