Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2376939..2377468 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag M1777_RS11175 Protein ID WP_003411124.1
Coordinates 2376939..2377256 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag M1777_RS11180 Protein ID WP_003411127.1
Coordinates 2377253..2377468 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS11145 (M1777_11155) 2372076..2373152 + 1077 WP_003411110.1 hypothetical protein -
M1777_RS11150 (M1777_11160) 2373149..2373430 + 282 WP_019283661.1 DUF5703 family protein -
M1777_RS11155 (M1777_11165) 2373466..2374539 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
M1777_RS11160 (M1777_11170) 2374544..2375074 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
M1777_RS11165 (M1777_11175) 2375122..2376468 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
M1777_RS11175 (M1777_11185) 2376939..2377256 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1777_RS11180 (M1777_11190) 2377253..2377468 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
M1777_RS11185 (M1777_11195) 2377723..2378781 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
M1777_RS11190 (M1777_11200) 2378911..2379267 - 357 WP_003411130.1 hypothetical protein -
M1777_RS11195 (M1777_11205) 2379362..2380144 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
M1777_RS11200 (M1777_11210) 2380412..2380702 - 291 WP_003900476.1 YggT family protein -
M1777_RS11205 (M1777_11215) 2380864..2381520 - 657 WP_003411133.1 cell division protein SepF -
M1777_RS11210 (M1777_11220) 2381586..2382362 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T243885 WP_003411124.1 NZ_CP096845:c2377256-2376939 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T243885 NZ_OX638703:c25796-25359 [Pseudomonas aeruginosa]
ATGAGCAAAAAGACGTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGCCCCGACGCGGTGCTGGCCAA
GCTGGAACAGGCAGTCACTAATCAGCACCGGATTGTCGTTTCGGCCATCACCTACTCCGAAATGCGTTTCGGGGCCGCCA
ACCCCAAGGCATCGCCCAAGGTTGCAGCGATGGTCGATGCCTTCATCCAGCGCCTGGACGCCATCCTGTCCTGGGACGCC
GCCGCCGTAGATCAAACAACGCAGATCCGCACCGCCCTCGCCCGCCTGGGTACGCCCATTGGCAACAACGATGCAGCGAT
AGCCGGCCATGCCCTGGCCGCTGGGTGTGTTCTGGTCACGAACAACACTCGCGAATTTGCTCGCGTTCCTGGCCTAGTCC
TTGAGGACTGGACCCAACCCGCCATTACCAAGAGTTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT243885 WP_003411127.1 NZ_CP096845:c2377468-2377253 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT243885 NZ_OX638703:c26029-25793 [Pseudomonas aeruginosa]
ATGCGTACCGTTTCCATTTTCATGAACAGCCGAAACCAGGCGATCCGCATCCCTCGGGATATGGAGTACCAGGGCGTTTC
CGAGCTGGAGATTATCCGCGACGGCGAAACGCTGATCCTGCGCCCTGTGCGCCCCTCCTGGGCATCGTTGCGCGACGTGG
CGGCCGCAGATCCTGACTTTCTGACCGAGCGAAAGGATGTGATCGAGGAAGACCGTTTCCTGGGTGACTTCACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References