243880

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2208719..2209305 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag M1777_RS10390 Protein ID WP_003410010.1
Coordinates 2208719..2209063 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag M1777_RS10395 Protein ID WP_003410014.1
Coordinates 2209057..2209305 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS10355 (M1777_10365) 2204425..2205024 + 600 WP_003409989.1 L-lysine exporter -
M1777_RS10360 (M1777_10370) 2205440..2205868 + 429 WP_003409992.1 cellulose-binding protein -
M1777_RS10365 (M1777_10375) 2206094..2206633 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1777_RS10370 (M1777_10380) 2207153..2207713 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
M1777_RS10375 (M1777_10385) 2207710..2208051 - 342 WP_003410003.1 DUF2384 domain-containing protein -
M1777_RS10380 (M1777_10390) 2208137..2208394 + 258 WP_003410006.1 hypothetical protein -
M1777_RS10385 (M1777_10395) 2208295..2208630 - 336 WP_003410009.1 dehydrogenase -
M1777_RS10390 (M1777_10400) 2208719..2209063 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
M1777_RS10395 (M1777_10405) 2209057..2209305 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
M1777_RS10400 (M1777_10410) 2209405..2211720 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M1777_RS10405 (M1777_10415) 2211717..2211989 - 273 WP_003410017.1 DUF1490 family protein -
M1777_RS10410 (M1777_10420) 2212042..2212398 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
M1777_RS10415 (M1777_10425) 2212555..2213322 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T243880 WP_003410010.1 NZ_CP096845:c2209063-2208719 [Mycobacterium tuberculosis variant bovis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T243880 NZ_CP096845:c2209063-2208719 [Mycobacterium tuberculosis variant bovis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT243880 WP_003410014.1 NZ_CP096845:c2209305-2209057 [Mycobacterium tuberculosis variant bovis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT243880 NZ_CP096845:c2209305-2209057 [Mycobacterium tuberculosis variant bovis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References