Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1730949..1731483 Replicon chromosome
Accession NC_013416
Organism Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D11S_RS08630 Protein ID WP_005545660.1
Coordinates 1731193..1731483 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D11S_RS08625 Protein ID WP_005545663.1
Coordinates 1730949..1731203 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D11S_RS08595 (D11S_1792) 1726687..1727784 + 1098 WP_005573948.1 histidinol-phosphate transaminase -
D11S_RS08600 (D11S_1793) 1727795..1729126 + 1332 WP_005545667.1 3-phosphoshikimate 1-carboxyvinyltransferase -
D11S_RS08605 (D11S_1794) 1729205..1729672 - 468 WP_005545666.1 ribonuclease HI -
D11S_RS08610 (D11S_1795) 1729740..1730501 + 762 WP_005545665.1 DNA polymerase III subunit epsilon -
D11S_RS08625 (D11S_1798) 1730949..1731203 + 255 WP_005545663.1 stability protein StbD Antitoxin
D11S_RS08630 (D11S_1799) 1731193..1731483 + 291 WP_005545660.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D11S_RS08635 (D11S_1800) 1731541..1731879 - 339 WP_012821089.1 cupin domain-containing protein -
D11S_RS08640 (D11S_1801) 1732220..1732672 + 453 WP_005540084.1 YeeE/YedE thiosulfate transporter family protein -
D11S_RS08645 (D11S_1802) 1732843..1734231 + 1389 WP_012821091.1 tRNA 5-hydroxyuridine modification protein YegQ -
D11S_RS08650 (D11S_1803) 1734528..1735619 + 1092 WP_005545654.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11481.33 Da        Isoelectric Point: 10.6936

>T24388 WP_005545660.1 NC_013416:1731193-1731483 [Aggregatibacter actinomycetemcomitans D11S-1]
MTYKLTFDKRALKEWEKLGDTIRQQFKNKLAERLENPRVPGDKLKGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLNAYKNAEFRQAR

Download         Length: 291 bp

>T24388 NC_013416:1731193-1731483 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGGAAAAGTTAGGTGACACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCCGGCGACAAATTAAAAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAAATGCATACAAAAATGCAGAATTCAGACAAGCCCGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9294.53 Da        Isoelectric Point: 3.9649

>AT24388 WP_005545663.1 NC_013416:1730949-1731203 [Aggregatibacter actinomycetemcomitans D11S-1]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT24388 NC_013416:1730949-1731203 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGGCAATACATCAAATTTTGACACAACAAGCCGCAAGCATTACCGATTTAAAACGGGACCCAATGGGCATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCGTAACCAACCGGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATCGCTGAAGAGCGTCTGGCGACCCTTGATCCGATTGAGGTAAGC
CTTGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References