Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2190814..2191358 | Replicon | chromosome |
| Accession | NZ_CP096845 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb1101 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | M1777_RS10265 | Protein ID | WP_003409896.1 |
| Coordinates | 2190814..2191110 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | M1777_RS10270 | Protein ID | WP_003409899.1 |
| Coordinates | 2191107..2191358 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1777_RS10210 (M1777_10220) | 2185847..2186197 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M1777_RS10215 (M1777_10225) | 2186208..2187110 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| M1777_RS10220 (M1777_10230) | 2187131..2187322 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M1777_RS10225 (M1777_10235) | 2187323..2187619 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M1777_RS10230 (M1777_10240) | 2187859..2188074 | + | 216 | WP_003409878.1 | antitoxin | - |
| M1777_RS10235 (M1777_10245) | 2188071..2188382 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1777_RS10240 (M1777_10250) | 2188356..2188877 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| M1777_RS10245 (M1777_10255) | 2188852..2189229 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| M1777_RS10250 (M1777_10260) | 2189271..2189720 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| M1777_RS10255 (M1777_10265) | 2189717..2190262 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M1777_RS10260 (M1777_10270) | 2190151..2190765 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M1777_RS10265 (M1777_10275) | 2190814..2191110 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M1777_RS10270 (M1777_10280) | 2191107..2191358 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| M1777_RS10275 (M1777_10285) | 2191345..2191839 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M1777_RS10280 (M1777_10290) | 2191999..2192406 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1777_RS10285 (M1777_10295) | 2192410..2192682 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1777_RS10290 (M1777_10300) | 2192715..2193935 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| M1777_RS10295 (M1777_10305) | 2194834..2195139 | + | 306 | Protein_2034 | ABC transporter permease | - |
| M1777_RS10300 (M1777_10310) | 2195135..2195215 | + | 81 | Protein_2035 | hypothetical protein | - |
| M1777_RS10305 (M1777_10315) | 2195323..2196171 | + | 849 | WP_273585820.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T243877 WP_003409896.1 NZ_CP096845:c2191110-2190814 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T243877 NZ_OX638701:c110788-110510 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT243877 WP_003409899.1 NZ_CP096845:c2191358-2191107 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT243877 NZ_OX638701:c110498-110193 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |