Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1948779..1949239 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag M1777_RS09160 Protein ID WP_003408531.1
Coordinates 1948991..1949239 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag M1777_RS09155 Protein ID WP_003408528.1
Coordinates 1948779..1948991 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS09140 (M1777_09145) 1945257..1946444 - 1188 WP_003898992.1 nitrate transporter NarK -
M1777_RS09145 (M1777_09150) 1946731..1947015 + 285 WP_003408522.1 DUF1876 domain-containing protein -
M1777_RS09150 (M1777_09155) 1947029..1948711 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
M1777_RS09155 (M1777_09160) 1948779..1948991 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1777_RS09160 (M1777_09165) 1948991..1949239 + 249 WP_003408531.1 hypothetical protein Toxin
M1777_RS09165 (M1777_09170) 1949247..1949985 + 739 Protein_1808 hypothetical protein -
M1777_RS09170 (M1777_09175) 1950079..1951779 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
M1777_RS09175 (M1777_09180) 1952064..1952465 - 402 WP_010950586.1 hypothetical protein -
M1777_RS09180 (M1777_09185) 1952455..1953066 - 612 Protein_1811 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T243874 WP_003408531.1 NZ_CP096845:1948991-1949239 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T243874 NZ_OX638611:36075-36353 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAGCAAGGCCCTATCCGATCTGGCCCGCCTCTATGAGTTTCTGGCGGCGGTGAACCGGCCAGC
AGCGGCCCGCACGGTGCAGCAGCTGACGGTTACACCGACCACACTGCTGACCAACCCGCGTATCGGCGAGCGGCTGGAAG
AATTCGAGCCGCGTGACGTGCGGCGGATTCTGGTCGGGCACTACGAGATGCGCTACGAAATTGCAGCGGACTCCACCATC
TACCTGCTGCGCCTGTGGCACACACGCGAGGATCGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT243874 WP_003408528.1 NZ_CP096845:1948779-1948991 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT243874 NZ_OX638611:35803-36075 [Pseudomonas aeruginosa]
ATGGCCGCTACCGCAAAAACCCGATCCGTCACCGCTCACGTCCCTGTCGAGCTGGCTGAACGTGTCGATGAAATCGCCGA
ACGCTTGGAGCGCTCGAAGAACTGGATCGTCAAGCAAGCACTGTCCGCCTGGCTCGACCAGGAAGAGGAACGCAGTCGCC
TGACCCGCGAGGCCCTGGCCGATGTGGATGCCGGGCGCGTGATCGACCATCAGGCCGTGCAGGCCTGGGCCGACAGCTTG
AGCACCGACACGCCGCTGCCGGTGCCGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References