Detailed information of TA system TA243868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1386696..1387255
• Replicon: chromosome
• Accession: NZ_CP096845
• Organism: Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: M1777_RS06655
• Protein ID: WP_003898789.1
• Coordinates: 1386696..1386989 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: M1777_RS06660
• Protein ID: WP_003406322.1
• Coordinates: 1386986..1387255 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1777_RS06630 (M1777_06625)	1382290..1382550	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
M1777_RS06635 (M1777_06630)	1382547..1382978	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
M1777_RS06640 (M1777_06635)	1383001..1384688	-	1688	Protein_1310	PE family protein	-
M1777_RS06645 (M1777_06640)	1384868..1385728	+	861	WP_003406306.1	glycine betaine ABC transporter substrate-binding protein	-
M1777_RS06650 (M1777_06645)	1385809..1386639	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
M1777_RS06655 (M1777_06650)	1386696..1386989	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
M1777_RS06660 (M1777_06655)	1386986..1387255	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1777_RS06665 (M1777_06660)	1387368..1391063	-	3696	WP_010950509.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
M1777_RS06670 (M1777_06665)	1391205..1391993	-	789	WP_010950510.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T243868 WP_003898789.1 NZ_CP096845:c1386989-1386696 [Mycobacterium tuberculosis variant bovis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T243868 NZ_OX638610:554816-555097 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT243868 WP_003406322.1 NZ_CP096845:c1387255-1386986 [Mycobacterium tuberculosis variant bovis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT243868 NZ_OX638610:554592-554819 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2