Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1228732..1229363 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag M1777_RS05905 Protein ID WP_003405820.1
Coordinates 1228732..1229043 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag M1777_RS05910 Protein ID WP_003405836.1
Coordinates 1229043..1229363 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS05885 (M1777_05885) 1224214..1225638 - 1425 WP_003405805.1 class II fumarate hydratase -
M1777_RS05890 (M1777_05890) 1225669..1226757 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
M1777_RS05895 (M1777_05895) 1226813..1227457 + 645 WP_174813088.1 DUF4245 domain-containing protein -
M1777_RS05900 (M1777_05900) 1227464..1228620 - 1157 Protein_1162 AI-2E family transporter -
M1777_RS05905 (M1777_05905) 1228732..1229043 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
M1777_RS05910 (M1777_05910) 1229043..1229363 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
M1777_RS05915 (M1777_05915) 1229373..1230909 + 1537 Protein_1165 carboxylesterase/lipase family protein -
M1777_RS05920 (M1777_05920) 1230916..1232028 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
M1777_RS05925 (M1777_05925) 1232038..1232295 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
M1777_RS05930 (M1777_05930) 1232285..1233532 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
M1777_RS05935 (M1777_05935) 1233529..1234167 - 639 WP_011799158.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T243865 WP_003405820.1 NZ_CP096845:c1229043-1228732 [Mycobacterium tuberculosis variant bovis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T243865 NZ_OX638564:c5436384-5436037 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT243865 WP_003405836.1 NZ_CP096845:c1229363-1229043 [Mycobacterium tuberculosis variant bovis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT243865 NZ_OX638564:c5436645-5436394 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References