Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 751253..751886 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag M1777_RS03475 Protein ID WP_003403365.1
Coordinates 751253..751636 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag M1777_RS03480 Protein ID WP_003403368.1
Coordinates 751731..751886 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS03450 (M1777_03450) 746545..747081 + 537 WP_003403341.1 50S ribosomal protein L10 -
M1777_RS03455 (M1777_03455) 747118..747510 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
M1777_RS03460 (M1777_03460) 747503..748198 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
M1777_RS03465 (M1777_03465) 748269..749774 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
M1777_RS03470 (M1777_03470) 749855..750865 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
M1777_RS03475 (M1777_03475) 751253..751636 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
M1777_RS03480 (M1777_03480) 751731..751886 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1777_RS03485 (M1777_03485) 751962..752678 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
M1777_RS03490 (M1777_03490) 752954..753262 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
M1777_RS03495 (M1777_03495) 753249..753494 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
M1777_RS03500 (M1777_03500) 753604..754041 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
M1777_RS03505 (M1777_03505) 754038..754292 - 255 WP_003911263.1 antitoxin VapB7 -
M1777_RS03510 (M1777_03510) 754406..756769 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T243857 WP_003403365.1 NZ_CP096845:c751636-751253 [Mycobacterium tuberculosis variant bovis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T243857 NZ_OX637964:c4976125-4975814 [Escherichia coli O25b:H4-ST131]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT243857 WP_003403368.1 NZ_CP096845:c751886-751731 [Mycobacterium tuberculosis variant bovis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT243857 NZ_OX637964:c4975813-4975523 [Escherichia coli O25b:H4-ST131]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References