Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 714156..714805 | Replicon | chromosome |
| Accession | NZ_CP096845 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb1101 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P67241 |
| Locus tag | M1777_RS03290 | Protein ID | WP_003403236.1 |
| Coordinates | 714410..714805 (+) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WJ34 |
| Locus tag | M1777_RS03285 | Protein ID | WP_003403235.1 |
| Coordinates | 714156..714410 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1777_RS03260 (M1777_03260) | 709281..709364 | + | 84 | Protein_646 | galactose-1-phosphate uridylyltransferase | - |
| M1777_RS03265 (M1777_03265) | 709383..710465 | + | 1083 | WP_031652152.1 | galactose-1-phosphate uridylyltransferase | - |
| M1777_RS03270 (M1777_03270) | 710462..711553 | + | 1092 | WP_003403225.1 | galactokinase | - |
| M1777_RS03275 (M1777_03275) | 711948..713105 | + | 1158 | WP_003903091.1 | hypothetical protein | - |
| M1777_RS03280 (M1777_03280) | 713116..714063 | + | 948 | WP_003403232.1 | DUF732 domain-containing protein | - |
| M1777_RS03285 (M1777_03285) | 714156..714410 | + | 255 | WP_003403235.1 | type II toxin-antitoxin system antitoxin VapB30 | Antitoxin |
| M1777_RS03290 (M1777_03290) | 714410..714805 | + | 396 | WP_003403236.1 | type II toxin-antitoxin system toxin ribonuclease C30 | Toxin |
| M1777_RS03295 (M1777_03295) | 714899..715639 | - | 741 | WP_003403239.1 | TVP38/TMEM64 family protein | - |
| M1777_RS03300 (M1777_03300) | 715771..716031 | + | 261 | WP_003403244.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1777_RS03305 (M1777_03305) | 716028..716435 | + | 408 | WP_003403246.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1777_RS03310 (M1777_03310) | 716507..717658 | - | 1152 | WP_003403248.1 | FIST N-terminal domain-containing protein | - |
| M1777_RS03315 (M1777_03315) | 717751..719478 | - | 1728 | WP_010950423.1 | exodeoxyribonuclease V subunit alpha | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14250.04 Da Isoelectric Point: 4.7475
>T243855 WP_003403236.1 NZ_CP096845:714410-714805 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP
Download Length: 396 bp
>T243855 NZ_OX637964:4610848-4611225 [Escherichia coli O25b:H4-ST131]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9139.52 Da Isoelectric Point: 9.2702
>AT243855 WP_003403235.1 NZ_CP096845:714156-714410 [Mycobacterium tuberculosis variant bovis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA
Download Length: 255 bp
>AT243855 NZ_OX637964:4610424-4610801 [Escherichia coli O25b:H4-ST131]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 4XGR | |
| PDB | 4XGQ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 4XGR | |
| PDB | 4XGQ | |
| AlphaFold DB | A0A7U4BSC2 |