Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 708527..709152 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag M1777_RS03255 Protein ID WP_003403218.1
Coordinates 708751..709152 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag M1777_RS03250 Protein ID WP_003403213.1
Coordinates 708527..708754 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS03225 (M1777_03225) 703706..703927 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M1777_RS03230 (M1777_03230) 704069..704674 + 606 WP_003898526.1 hypothetical protein -
M1777_RS03235 (M1777_03235) 704693..707260 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
M1777_RS03240 (M1777_03240) 707344..708093 + 750 WP_003898528.1 hypothetical protein -
M1777_RS03245 (M1777_03245) 708090..708332 + 243 WP_003403210.1 hypothetical protein -
M1777_RS03250 (M1777_03250) 708527..708754 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
M1777_RS03255 (M1777_03255) 708751..709152 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
M1777_RS03260 (M1777_03260) 709281..709364 + 84 Protein_646 galactose-1-phosphate uridylyltransferase -
M1777_RS03265 (M1777_03265) 709383..710465 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1777_RS03270 (M1777_03270) 710462..711553 + 1092 WP_003403225.1 galactokinase -
M1777_RS03275 (M1777_03275) 711948..713105 + 1158 WP_003903091.1 hypothetical protein -
M1777_RS03280 (M1777_03280) 713116..714063 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T243854 WP_003403218.1 NZ_CP096845:708751-709152 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T243854 NZ_OX637964:c4438481-4438131 [Escherichia coli O25b:H4-ST131]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT243854 WP_003403213.1 NZ_CP096845:708527-708754 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT243854 NZ_OX637964:c4438726-4438475 [Escherichia coli O25b:H4-ST131]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References