Detailed information of TA system TA024385

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1345416..1345951
• Replicon: chromosome
• Accession: NC_013416
• Organism: Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D11S_RS06790
• Protein ID: WP_005546120.1
• Coordinates: 1345667..1345951 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D11S_RS06785
• Protein ID: WP_005574425.1
• Coordinates: 1345416..1345670 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D11S_RS06775 (D11S_1414)	1342733..1343512	-	780	WP_005546112.1	MmcQ/YjbR family DNA-binding protein	-
D11S_RS06780 (D11S_1415)	1343742..1345199	+	1458	WP_005546115.1	DASS family sodium-coupled anion symporter	-
D11S_RS06785 (D11S_1417)	1345416..1345670	+	255	WP_005574425.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D11S_RS06790 (D11S_1418)	1345667..1345951	+	285	WP_005546120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D11S_RS06795 (D11S_1419)	1345964..1346749	-	786	WP_005574423.1	tRNA pseudouridine(38-40) synthase TruA	-
D11S_RS06800 (D11S_1421)	1346912..1347304	-	393	WP_005546123.1	30S ribosomal protein S9	-
D11S_RS06805 (D11S_1422)	1347321..1347749	-	429	WP_005546126.1	50S ribosomal protein L13	-
D11S_RS06810 (D11S_1423)	1347993..1348589	-	597	WP_005546127.1	class I SAM-dependent methyltransferase	-
D11S_RS06815 (D11S_1424)	1348602..1350581	-	1980	WP_005546129.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11175.17 Da
• Isoelectric Point: 10.6072

>T24385 WP_005546120.1 NC_013416:1345667-1345951 [Aggregatibacter actinomycetemcomitans D11S-1]
MSYIIEFIPSSEKEFRKLDINLRKQFIEKLKERAENPRVSSAKLHGMKDCYKIKLRNVGYHLVYQVIDERIVVKAISVGK
RDRNFVYTKAKSRL

Nucleotide

• Length: 285 bp

>T24385 NC_013416:1345667-1345951 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGAGTTACATCATTGAGTTTATCCCATCATCTGAAAAAGAATTCCGCAAACTCGATATTAATCTGCGTAAACAATTCAT
TGAGAAATTAAAAGAACGCGCCGAAAATCCCCGAGTGTCATCCGCCAAATTACACGGCATGAAAGATTGCTATAAAATCA
AATTACGCAATGTAGGGTATCATTTGGTGTATCAGGTTATTGATGAACGCATTGTGGTCAAAGCCATCTCCGTAGGAAAA
CGCGATCGAAATTTTGTTTATACCAAAGCAAAAAGCAGGCTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9462.91 Da
• Isoelectric Point: 4.1191

>AT24385 WP_005574425.1 NC_013416:1345416-1345670 [Aggregatibacter actinomycetemcomitans D11S-1]
MTSLVLTDVVASITELKTNPMAVLREAGGKPLAILNRNEPAFYCVPPAIYEYLMELVDDAELTKIVEERQHEKSYPVDLE
DLLQ

Nucleotide

• Length: 255 bp

>AT24385 NC_013416:1345416-1345670 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGACAAGCCTTGTTTTAACCGATGTTGTCGCCAGTATCACCGAATTAAAAACTAATCCCATGGCGGTACTTCGTGAAGC
CGGTGGAAAACCGCTGGCAATTTTAAACCGCAATGAACCCGCATTTTATTGCGTCCCACCGGCAATTTATGAATATTTGA
TGGAATTAGTCGATGATGCTGAATTGACAAAAATCGTGGAAGAACGTCAACATGAAAAAAGTTATCCTGTTGATTTAGAG
GATTTACTACAATGA