Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 361822..362465 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag M1777_RS01595 Protein ID WP_003401566.1
Coordinates 362040..362465 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag M1777_RS01590 Protein ID WP_003401563.1
Coordinates 361822..362043 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS01565 (M1777_01565) 356896..357699 - 804 WP_003401540.1 Stf0 family sulphotransferase -
M1777_RS01570 (M1777_01570) 357709..359106 - 1398 WP_003401544.1 sulfatase -
M1777_RS01575 (M1777_01575) 359285..361105 + 1821 WP_003401546.1 PE family protein -
M1777_RS01580 (M1777_01580) 361248..361475 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
M1777_RS01585 (M1777_01585) 361472..361774 + 303 WP_003401560.1 toxin-antitoxin system toxin -
M1777_RS01590 (M1777_01590) 361822..362043 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
M1777_RS01595 (M1777_01595) 362040..362465 + 426 WP_003401566.1 PIN domain nuclease Toxin
M1777_RS01600 (M1777_01600) 362601..363233 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
M1777_RS01605 (M1777_01605) 363230..364138 + 909 WP_003900117.1 protochlorophyllide reductase -
M1777_RS01610 (M1777_01610) 364146..364736 - 591 WP_234712434.1 hypothetical protein -
M1777_RS01615 (M1777_01615) 364729..364779 - 51 Protein_319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T243848 WP_003401566.1 NZ_CP096845:362040-362465 [Mycobacterium tuberculosis variant bovis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T243848 NZ_OX637964:c3667780-3667478 [Escherichia coli O25b:H4-ST131]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT243848 WP_003401563.1 NZ_CP096845:361822-362043 [Mycobacterium tuberculosis variant bovis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT243848 NZ_OX637964:c3667442-3667101 [Escherichia coli O25b:H4-ST131]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References