Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3077076..3077646 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag M1776_RS14620 Protein ID WP_003414166.1
Coordinates 3077076..3077432 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag M1776_RS14625 Protein ID WP_003901465.1
Coordinates 3077416..3077646 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS14600 (M1776_14610) 3072528..3074216 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
M1776_RS14605 (M1776_14615) 3074220..3074546 - 327 WP_003414157.1 hypothetical protein -
M1776_RS14610 (M1776_14620) 3074719..3075306 + 588 WP_003914429.1 DUF3558 family protein -
M1776_RS14615 (M1776_14625) 3075325..3076974 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
M1776_RS14620 (M1776_14630) 3077076..3077432 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
M1776_RS14625 (M1776_14635) 3077416..3077646 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
M1776_RS14630 (M1776_14640) 3077689..3078732 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
M1776_RS14635 (M1776_14645) 3078731..3079198 + 468 WP_003414177.1 DUF1778 domain-containing protein -
M1776_RS14640 (M1776_14650) 3079374..3079628 - 255 WP_003917684.1 hypothetical protein -
M1776_RS14645 (M1776_14655) 3079776..3080180 + 405 WP_003414181.1 hypothetical protein -
M1776_RS14650 (M1776_14660) 3080177..3080368 + 192 WP_003414184.1 hypothetical protein -
M1776_RS14655 (M1776_14665) 3080585..3080845 + 261 Protein_2892 transposase -
M1776_RS14660 (M1776_14670) 3081955..3082212 + 258 WP_003899489.1 hypothetical protein -
M1776_RS14665 (M1776_14675) 3082317..3082628 + 312 WP_010950777.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T243836 WP_003414166.1 NZ_CP096844:c3077432-3077076 [Mycobacterium tuberculosis variant bovis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T243836 NZ_OX637964:186212-186319 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT243836 WP_003901465.1 NZ_CP096844:c3077646-3077416 [Mycobacterium tuberculosis variant bovis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT243836 NZ_OX637964:c186163-186098 [Escherichia coli O25b:H4-ST131]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References