Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3037080..3037759 | Replicon | chromosome |
| Accession | NZ_CP096844 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb1855 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | M1776_RS14390 | Protein ID | WP_003414059.1 |
| Coordinates | 3037080..3037496 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | M1776_RS14395 | Protein ID | WP_003414061.1 |
| Coordinates | 3037493..3037759 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1776_RS14370 (M1776_14375) | 3033132..3034034 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| M1776_RS14375 (M1776_14380) | 3034103..3034855 | - | 753 | WP_069523501.1 | FAD-dependent thymidylate synthase | - |
| M1776_RS14380 (M1776_14390) | 3035099..3035374 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| M1776_RS14385 (M1776_14395) | 3035371..3036993 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| M1776_RS14390 (M1776_14400) | 3037080..3037496 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| M1776_RS14395 (M1776_14405) | 3037493..3037759 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| M1776_RS14400 (M1776_14410) | 3037785..3038180 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1776_RS14405 (M1776_14415) | 3038177..3038446 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| M1776_RS14410 (M1776_14420) | 3038456..3039550 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| M1776_RS14415 (M1776_14425) | 3039547..3039966 | - | 420 | Protein_2844 | winged helix-turn-helix domain-containing protein | - |
| M1776_RS14420 (M1776_14430) | 3039965..3040039 | + | 75 | Protein_2845 | hypothetical protein | - |
| M1776_RS14425 (M1776_14435) | 3040040..3040519 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| M1776_RS14430 (M1776_14440) | 3040590..3041390 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| M1776_RS14435 (M1776_14445) | 3041546..3042283 | + | 738 | WP_011799288.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T243834 WP_003414059.1 NZ_CP096844:c3037496-3037080 [Mycobacterium tuberculosis variant bovis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T243834 NZ_OX637962:c127863-127558 [Escherichia coli O25b:H4-ST131]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT243834 WP_003414061.1 NZ_CP096844:c3037759-3037493 [Mycobacterium tuberculosis variant bovis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT243834 NZ_OX637962:c128083-127865 [Escherichia coli O25b:H4-ST131]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|