Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2907922..2908636 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag M1776_RS13640 Protein ID WP_003413460.1
Coordinates 2908196..2908636 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag M1776_RS13635 Protein ID WP_003413456.1
Coordinates 2907922..2908209 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS13600 (M1776_13605) 2903344..2903589 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
M1776_RS13605 (M1776_13610) 2903586..2903990 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
M1776_RS13610 (M1776_13615) 2904207..2904827 + 621 WP_003413441.1 DUF4178 domain-containing protein -
M1776_RS13615 (M1776_13620) 2904838..2905332 + 495 WP_003413444.1 DUF2617 family protein -
M1776_RS13620 (M1776_13625) 2905329..2905760 + 432 WP_003413445.1 DUF4247 domain-containing protein -
M1776_RS13625 (M1776_13630) 2905785..2906243 + 459 WP_003413451.1 DUF350 domain-containing protein -
M1776_RS13630 (M1776_13635) 2906240..2907811 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
M1776_RS13635 (M1776_13640) 2907922..2908209 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
M1776_RS13640 (M1776_13645) 2908196..2908636 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
M1776_RS13645 (M1776_13650) 2908657..2909412 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
M1776_RS13650 (M1776_13655) 2909545..2910141 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
M1776_RS13655 (M1776_13660) 2910149..2910994 - 846 WP_010950749.1 acyl-CoA thioesterase II -
M1776_RS13660 (M1776_13665) 2911023..2911922 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
M1776_RS13665 (M1776_13670) 2912050..2912724 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T243833 WP_003413460.1 NZ_CP096844:2908196-2908636 [Mycobacterium tuberculosis variant bovis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T243833 NZ_OX637962:c66832-66698 [Escherichia coli O25b:H4-ST131]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT243833 WP_003413456.1 NZ_CP096844:2907922-2908209 [Mycobacterium tuberculosis variant bovis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT243833 NZ_OX637962:66877-66937 [Escherichia coli O25b:H4-ST131]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References