Detailed information of TA system TA243829

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2831459..2832099
• Replicon: chromosome
• Accession: NZ_CP096844
• Organism: Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: M1776_RS13265
• Protein ID: WP_003412970.1
• Coordinates: 2831459..2831878 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: M1776_RS13270
• Protein ID: WP_003412975.1
• Coordinates: 2831875..2832099 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1776_RS13235 (M1776_13240)	2827044..2827766	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
M1776_RS13240 (M1776_13245)	2828283..2828510	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
M1776_RS13245 (M1776_13250)	2828507..2828908	+	402	WP_003412963.1	PIN domain-containing protein	-
M1776_RS13250 (M1776_13255)	2828943..2829863	-	921	WP_011799273.1	restriction endonuclease	-
M1776_RS13255 (M1776_13260)	2830204..2830410	-	207	WP_229298035.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
M1776_RS13260 (M1776_13265)	2830508..2831458	+	951	WP_162305733.1	ERCC4 domain-containing protein	-
M1776_RS13265 (M1776_13270)	2831459..2831878	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
M1776_RS13270 (M1776_13275)	2831875..2832099	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
M1776_RS13275 (M1776_13280)	2832130..2834973	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
M1776_RS13280 (M1776_13285)	2835045..2835446	-	402	WP_003412981.1	hypothetical protein	-
M1776_RS13285 (M1776_13290)	2835446..2835916	-	471	WP_003412985.1	transcription antitermination factor NusB	-
M1776_RS13290 (M1776_13295)	2835919..2836482	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T243829 WP_003412970.1 NZ_CP096844:c2831878-2831459 [Mycobacterium tuberculosis variant bovis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T243829 NZ_OX637961:c3989552-3989238 [Escherichia coli O25b:H4-ST131]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT243829 WP_003412975.1 NZ_CP096844:c2832099-2831875 [Mycobacterium tuberculosis variant bovis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT243829 NZ_OX637961:c3989788-3989555 [Escherichia coli O25b:H4-ST131]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09