Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2356247..2356942 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag M1776_RS11000 Protein ID WP_003410811.1
Coordinates 2356247..2356681 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag M1776_RS11005 Protein ID WP_003410814.1
Coordinates 2356688..2356942 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS10990 (M1776_11000) 2352401..2355442 + 3042 WP_069523450.1 DEAD/DEAH box helicase -
M1776_RS10995 (M1776_11005) 2355435..2356268 + 834 WP_003899172.1 SWIM zinc finger family protein -
M1776_RS11000 (M1776_11010) 2356247..2356681 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
M1776_RS11005 (M1776_11015) 2356688..2356942 - 255 WP_003410814.1 antitoxin Antitoxin
M1776_RS11010 (M1776_11020) 2356958..2357215 - 258 WP_003410816.1 hypothetical protein -
M1776_RS11015 (M1776_11025) 2358162..2358458 + 297 WP_003410820.1 PE family protein -
M1776_RS11020 (M1776_11030) 2358514..2359245 + 732 WP_003900467.1 PPE family protein -
M1776_RS11025 (M1776_11035) 2359785..2360531 - 747 WP_003901330.1 proteasome subunit alpha -
M1776_RS11030 (M1776_11040) 2360528..2361403 - 876 WP_003411023.1 proteasome subunit beta -
M1776_RS11035 (M1776_11045) 2361400..2361594 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T243826 WP_003410811.1 NZ_CP096844:c2356681-2356247 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T243826 NZ_OX637961:c3568249-3567947 [Escherichia coli O25b:H4-ST131]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT243826 WP_003410814.1 NZ_CP096844:c2356942-2356688 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT243826 NZ_OX637961:c3567911-3567570 [Escherichia coli O25b:H4-ST131]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References