Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mbcAT/RES-TIGR02293 |
| Location | 2222036..2222934 | Replicon | chromosome |
| Accession | NZ_CP096844 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb1855 | ||
Toxin (Protein)
| Gene name | mbcT | Uniprot ID | - |
| Locus tag | M1776_RS10400 | Protein ID | WP_069523395.1 |
| Coordinates | 2222036..2222596 (-) | Length | 187 a.a. |
Antitoxin (Protein)
| Gene name | mbcA | Uniprot ID | P64910 |
| Locus tag | M1776_RS10405 | Protein ID | WP_003410003.1 |
| Coordinates | 2222593..2222934 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1776_RS10370 (M1776_10375) | 2217205..2217858 | - | 654 | WP_003409976.1 | cutinase Cfp21 | - |
| M1776_RS10375 (M1776_10380) | 2217973..2218203 | + | 231 | WP_003409980.1 | DUF167 domain-containing protein | - |
| M1776_RS10380 (M1776_10385) | 2218288..2219199 | - | 912 | WP_003409986.1 | ArgP/LysG family DNA-binding transcriptional regulator | - |
| M1776_RS10385 (M1776_10390) | 2219308..2219907 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
| M1776_RS10390 (M1776_10395) | 2220323..2220751 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
| M1776_RS10395 (M1776_10400) | 2220977..2221516 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| M1776_RS10400 (M1776_10405) | 2222036..2222596 | - | 561 | WP_069523395.1 | RES domain-containing protein | Toxin |
| M1776_RS10405 (M1776_10410) | 2222593..2222934 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | Antitoxin |
| M1776_RS10410 (M1776_10415) | 2223020..2223277 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| M1776_RS10415 (M1776_10420) | 2223178..2223513 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| M1776_RS10420 (M1776_10425) | 2223602..2223946 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | - |
| M1776_RS10425 (M1776_10430) | 2223940..2224188 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | - |
| M1776_RS10430 (M1776_10435) | 2224288..2226603 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| M1776_RS10435 (M1776_10440) | 2226600..2226872 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
| M1776_RS10440 (M1776_10445) | 2226925..2227281 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 187 a.a. Molecular weight: 20308.80 Da Isoelectric Point: 4.5091
>T243821 WP_069523395.1 NZ_CP096844:c2222596-2222036 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADFAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADFAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT
Download Length: 561 bp
>T243821 NZ_OX637961:2129932-2130034 [Escherichia coli O25b:H4-ST131]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 114 a.a. Molecular weight: 12488.33 Da Isoelectric Point: 4.8359
>AT243821 WP_003410003.1 NZ_CP096844:c2222934-2222593 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV
Download Length: 342 bp
>AT243821 NZ_OX637961:c2130072-2129804 [Escherichia coli O25b:H4-ST131]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|