Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1940268..1940881 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag M1776_RS09070 Protein ID WP_003408465.1
Coordinates 1940268..1940657 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag M1776_RS09075 Protein ID WP_003408469.1
Coordinates 1940654..1940881 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS09035 (M1776_09045) 1935898..1936812 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
M1776_RS09040 (M1776_09050) 1936815..1937645 + 831 WP_003408448.1 cyclase family protein -
M1776_RS09045 (M1776_09055) 1937645..1937995 + 351 WP_003898986.1 cupin domain-containing protein -
M1776_RS09050 (M1776_09060) 1938048..1938865 + 818 Protein_1786 3-keto-5-aminohexanoate cleavage protein -
M1776_RS09055 (M1776_09065) 1938879..1939658 + 780 WP_069523281.1 IclR family transcriptional regulator -
M1776_RS09065 (M1776_09075) 1940089..1940220 + 132 Protein_1788 IS3 family transposase -
M1776_RS09070 (M1776_09080) 1940268..1940657 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
M1776_RS09075 (M1776_09085) 1940654..1940881 - 228 WP_003408469.1 antitoxin Antitoxin
M1776_RS09080 (M1776_09090) 1941099..1942583 + 1485 WP_010950580.1 biotin carboxylase -
M1776_RS09085 (M1776_09095) 1942580..1943827 + 1248 WP_003408476.1 serine hydrolase -
M1776_RS09090 (M1776_09100) 1943870..1944289 - 420 WP_003408483.1 hypothetical protein -
M1776_RS09095 (M1776_09105) 1944279..1944989 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T243815 WP_003408465.1 NZ_CP096844:c1940657-1940268 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T243815 NZ_OX637961:643351-643665 [Escherichia coli O25b:H4-ST131]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT243815 WP_003408469.1 NZ_CP096844:c1940881-1940654 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT243815 NZ_OX637961:643662-644078 [Escherichia coli O25b:H4-ST131]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References