Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1540806..1541856 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag M1776_RS07300 Protein ID WP_003407164.1
Coordinates 1540806..1541627 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag M1776_RS07305 Protein ID WP_003407167.1
Coordinates 1541620..1541856 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS07280 (M1776_07290) 1536364..1537026 - 663 WP_010950531.1 hypothetical protein -
M1776_RS07285 (M1776_07295) 1537023..1537808 - 786 WP_003407157.1 membrane protein -
M1776_RS07290 (M1776_07300) 1538099..1540060 - 1962 WP_010950533.1 sigma-F factor regulator -
M1776_RS07295 (M1776_07305) 1540199..1540585 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
M1776_RS07300 (M1776_07310) 1540806..1541627 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
M1776_RS07305 (M1776_07315) 1541620..1541856 + 237 WP_003407167.1 hypothetical protein Antitoxin
M1776_RS07310 (M1776_07320) 1541928..1543133 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
M1776_RS07315 (M1776_07325) 1543436..1544221 + 786 WP_069523269.1 lipoprotein LprF -
M1776_RS07320 (M1776_07330) 1544417..1545886 + 1470 Protein_1441 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T243811 WP_003407164.1 NZ_CP096844:1540806-1541627 [Mycobacterium tuberculosis variant bovis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T243811 NZ_OX637961:188058-188165 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT243811 WP_003407167.1 NZ_CP096844:1541620-1541856 [Mycobacterium tuberculosis variant bovis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT243811 NZ_OX637961:c188009-187944 [Escherichia coli O25b:H4-ST131]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References