Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 985647..986316 Replicon chromosome
Accession NC_013416
Organism Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag D11S_RS11270 Protein ID WP_005573679.1
Coordinates 985647..985985 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D11S_RS05080 Protein ID WP_005545810.1
Coordinates 986035..986316 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D11S_RS05050 981082..981510 + 429 WP_019518326.1 DUF2726 domain-containing protein -
D11S_RS05055 (D11S_1066) 981594..984458 + 2865 WP_005545802.1 valine--tRNA ligase -
D11S_RS05060 (D11S_1067) 984525..985418 + 894 WP_005545804.1 hypothetical protein -
D11S_RS11265 (D11S_1068) 985537..985653 - 117 WP_005545808.1 hypothetical protein -
D11S_RS11270 985647..985985 - 339 WP_005573679.1 HipA N-terminal domain-containing protein Toxin
D11S_RS05080 (D11S_1070) 986035..986316 - 282 WP_005545810.1 helix-turn-helix domain-containing protein Antitoxin
D11S_RS05085 (D11S_1071) 986460..987977 - 1518 WP_012820965.1 DHA2 family efflux MFS transporter permease subunit -
D11S_RS05090 (D11S_02595) 987987..989148 - 1162 Protein_970 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
D11S_RS05095 (D11S_1074) 989357..989839 + 483 WP_005544145.1 Dps family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13104.85 Da        Isoelectric Point: 8.6930

>T24381 WP_005573679.1 NC_013416:c985985-985647 [Aggregatibacter actinomycetemcomitans D11S-1]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPDNEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYAEPLNDKKCKTC

Download         Length: 339 bp

>T24381 NC_013416:c985985-985647 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGGCGAAAGCTCACAAATGGCCGACGGAATTTCAATATCCCCCAAAATGGCTTGATTCTGCGCGCTCCCGTCCAATTTC
ATTATCATTGCCTTTATCCCATAAAGTTTACCGAGAGGATTCGGTTTACAATTTCTTCGATAATCTTTTGCCCGACAATG
AACAAATTCGTTCACGCATTCAGCAACGTTTCCAGACCTCGACCAAATCCCCCTTTGATTTGCTTTCGGCTATTGAGCAG
GATTGCGTTGGGGCGATTCAACTTTATCACGGTGAAAGTCGCTCTGTTCGGCAAATTTATGCGGAGCCGTTAAATGATAA
GAAGTGTAAAACGTGTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10520.06 Da        Isoelectric Point: 4.8356

>AT24381 WP_005545810.1 NC_013416:c986316-986035 [Aggregatibacter actinomycetemcomitans D11S-1]
MVITIAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Download         Length: 282 bp

>AT24381 NC_013416:c986316-986035 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGGTTATTACCATCGCAAAAATGCTTTCTCATGTTATTCGGGAATTTCGTTATCAAGGCAACCTCTCACAAACAGATGT
CGCCAAGCTTGCTAGCACCACCCAAGCCAGAATATCGGTTTTTGAAAATGAGCCGGAACGCACGAAATTAGAAACGTTAT
TTAAAATTTTGGCAGGATTAGAGTTAGAACTTATCGTACAACCGCGCAAAAAATCCGCGGTTACGGAAAATTTAATCAGC
GAACCAACACCTGCATTTTCCGATGACGATGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References