243803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 842766..843475 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4F979
Locus tag M1776_RS03990 Protein ID WP_003903160.1
Coordinates 843047..843475 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag M1776_RS03985 Protein ID WP_003403834.1
Coordinates 842766..843023 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS03975 (M1776_03975) 839949..842471 + 2523 Protein_786 PE family protein -
M1776_RS03980 (M1776_03980) 842481..842675 + 195 WP_003910194.1 hypothetical protein -
M1776_RS03985 (M1776_03985) 842766..843023 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
M1776_RS03990 (M1776_03990) 843047..843475 + 429 WP_003903160.1 type II toxin-antitoxin system VapC family toxin Toxin
M1776_RS03995 (M1776_03995) 843556..843693 - 138 WP_003403839.1 hypothetical protein -
M1776_RS04000 (M1776_04005) 843852..844097 + 246 WP_003403841.1 hypothetical protein -
M1776_RS04005 (M1776_04010) 844166..845050 - 885 WP_011799127.1 3-hydroxyisobutyrate dehydrogenase -
M1776_RS04010 (M1776_04015) 845061..846233 - 1173 WP_010950438.1 acyl-CoA dehydrogenase family protein -
M1776_RS04015 (M1776_04020) 846240..847772 - 1533 WP_069523346.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15799.21 Da        Isoelectric Point: 7.5536

>T243803 WP_003903160.1 NZ_CP096844:843047-843475 [Mycobacterium tuberculosis variant bovis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLVLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T243803 NZ_OX637959:3601071-3601289 [Escherichia coli O25b:H4-ST131]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT243803 WP_003403834.1 NZ_CP096844:842766-843023 [Mycobacterium tuberculosis variant bovis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT243803 NZ_OX637959:3600671-3601045 [Escherichia coli O25b:H4-ST131]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F979

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References