Detailed information of TA system TA024380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/COG3657-dnstrm_HI1420
• Location: 942313..942905
• Replicon: chromosome
• Accession: NC_013416
• Organism: Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D11S_RS04855
• Protein ID: WP_012820951.1
• Coordinates: 942313..942624 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D11S_RS04860
• Protein ID: WP_005545245.1
• Coordinates: 942609..942905 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D11S_RS04830 (D11S_1018)	937591..938805	-	1215	WP_005545234.1	molybdopterin molybdotransferase MoeA	-
D11S_RS04835 (D11S_1019)	938934..939590	+	657	WP_005545236.1	GTP cyclohydrolase I FolE	-
D11S_RS04840 (D11S_1020)	939689..941131	-	1443	WP_005545239.1	serine-type D-Ala-D-Ala carboxypeptidase	-
D11S_RS04845 (D11S_1021)	941292..941768	+	477	WP_005542429.1	transcription elongation factor GreA	-
D11S_RS04850 (D11S_1022)	941843..942145	-	303	WP_005545243.1	ribosome assembly RNA-binding protein YhbY	-
D11S_RS04855 (D11S_1023)	942313..942624	+	312	WP_012820951.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D11S_RS04860 (D11S_1024)	942609..942905	+	297	WP_005545245.1	putative addiction module antidote protein	Antitoxin
D11S_RS04865 (D11S_1025)	942938..943552	-	615	WP_005575423.1	riboflavin synthase	-
D11S_RS04870 (D11S_1026)	943579..944976	+	1398	WP_012820952.1	MATE family efflux transporter	-
D11S_RS04875 (D11S_1027)	945281..945760	-	480	WP_005545251.1	Cys-tRNA(Pro) deacylase	-
D11S_RS04880 (D11S_1028)	945821..946792	+	972	WP_005545253.1	oxidoreductase	-
D11S_RS04885 (D11S_1029)	946848..947171	+	324	WP_005575427.1	DUF1919 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-92)

Antitoxin

• Uncharacterized protein HI1420 (6-94)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11921.03 Da
• Isoelectric Point: 10.4825

>T24380 WP_012820951.1 NC_013416:942313-942624 [Aggregatibacter actinomycetemcomitans D11S-1]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGLWVNN

Nucleotide

• Length: 312 bp

>T24380 NC_013416:942313-942624 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGAGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGGGTGAACAATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10853.30 Da
• Isoelectric Point: 4.2702

>AT24380 WP_005545245.1 NC_013416:942609-942905 [Aggregatibacter actinomycetemcomitans D11S-1]
MGEQLKDFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Nucleotide

• Length: 297 bp

>AT24380 NC_013416:942609-942905 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGGGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTACGCTTCTTAG