Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 754389..755022 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag M1776_RS03480 Protein ID WP_003403365.1
Coordinates 754389..754772 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag M1776_RS03485 Protein ID WP_003403368.1
Coordinates 754867..755022 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS03455 (M1776_03455) 749681..750217 + 537 WP_003403341.1 50S ribosomal protein L10 -
M1776_RS03460 (M1776_03460) 750254..750646 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
M1776_RS03465 (M1776_03465) 750639..751334 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
M1776_RS03470 (M1776_03470) 751405..752910 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
M1776_RS03475 (M1776_03475) 752991..754001 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
M1776_RS03480 (M1776_03480) 754389..754772 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
M1776_RS03485 (M1776_03485) 754867..755022 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1776_RS03490 (M1776_03490) 755098..755814 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
M1776_RS03495 (M1776_03495) 756090..756398 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
M1776_RS03500 (M1776_03500) 756385..756630 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
M1776_RS03505 (M1776_03505) 756740..757177 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
M1776_RS03510 (M1776_03510) 757174..757428 - 255 WP_003911263.1 antitoxin VapB7 -
M1776_RS03515 (M1776_03515) 757542..759905 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T243799 WP_003403365.1 NZ_CP096844:c754772-754389 [Mycobacterium tuberculosis variant bovis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T243799 NZ_OX637959:2664852-2664959 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT243799 WP_003403368.1 NZ_CP096844:c755022-754867 [Mycobacterium tuberculosis variant bovis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT243799 NZ_OX637959:c2664795-2664740 [Escherichia coli O25b:H4-ST131]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References