Detailed information of TA system TA024379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2182000..2183721
• Replicon: chromosome
• Accession: NC_013410
• Organism: Fibrobacter succinogenes subsp. succinogenes S85

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: C9RS34
• Locus tag: FISUC_RS08870
• Protein ID: WP_014546446.1
• Coordinates: 2182000..2183295 (-)
• Length: 432 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: FISUC_RS08875
• Protein ID: WP_014546447.1
• Coordinates: 2183305..2183721 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FISUC_RS08860	2179354..2181420	+	2067	WP_014546444.1	family 43 glycosylhydrolase	-
FISUC_RS08865	2181537..2182010	+	474	WP_015732108.1	hypothetical protein	-
FISUC_RS08870	2182000..2183295	-	1296	WP_014546446.1	type II toxin-antitoxin system HipA family toxin	Toxin
FISUC_RS08875	2183305..2183721	-	417	WP_014546447.1	helix-turn-helix domain-containing protein	Antitoxin
FISUC_RS08880	2183859..2184938	+	1080	WP_014546448.1	DUF285 domain-containing protein	-
FISUC_RS08885	2185002..2185910	+	909	WP_014546449.1	hypothetical protein	-
FISUC_RS08890	2185922..2186275	-	354	WP_015732109.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-73)

Sequences

Toxin

Protein

• Length: 432 a.a.
• Molecular weight: 48321.29 Da
• Isoelectric Point: 8.7287

>T24379 WP_014546446.1 NC_013410:c2183295-2182000 [Fibrobacter succinogenes subsp. succinogenes S85]
MIAVEVKLWGTTIGALSMMEGESVARFEYAPNFIGAGIEPSPIAMPVSRQIYSFPMLSKTFHGLPGLFADSLPDKFGNSI
IDTWLLRQGRSPESFTALERLCYTGNRGMGALEFFPLQGPDSTTDDSLNVENLRILAAEVLNQRKRFSTKALSKKGNKSF
EEILRVGTSAGGARAKILVAYDEESGEMHSGQVATDPRFGYWLLKLDDVTNNRDKESADLFGYGAIEYSYSQMAKLAGIE
MTECRLYECAGHRHFMTRRFDRLAGGKKLHYQSLCGIAHYDFNMPGAYSYEQALNVIKRLELGYDALEEMYRRAAFNICA
RNQDDHAKNIGFLMDKRGVWTLAPAFDMTYAYNPQGTWTGTHQMTFNGKRSGFKLDDFKAVAKFAGLKQGRYKKILAEVE
DAVMQWKKLAKQNGVPIRIARAIAGVHEFIL

Nucleotide

• Length: 1296 bp

>T24379 NC_013410:c2183295-2182000 [Fibrobacter succinogenes subsp. succinogenes S85]
ATGATTGCGGTGGAAGTAAAACTTTGGGGAACGACAATCGGGGCGCTTTCAATGATGGAAGGCGAAAGCGTTGCGCGTTT
TGAATACGCGCCGAACTTTATCGGGGCGGGCATTGAGCCCTCACCCATCGCCATGCCGGTCTCTCGGCAGATTTATTCGT
TCCCGATGTTATCAAAGACATTTCATGGACTGCCTGGGCTTTTTGCAGATAGCCTCCCGGACAAGTTCGGCAATAGCATT
ATTGACACATGGCTTTTACGGCAAGGGCGTTCACCAGAAAGTTTCACAGCACTCGAACGCTTGTGTTATACGGGCAACCG
GGGCATGGGCGCACTGGAGTTTTTTCCATTACAGGGACCAGATTCTACAACGGACGATTCTTTAAACGTTGAAAACTTGA
GAATTTTAGCAGCGGAAGTCTTGAATCAGCGCAAACGATTTTCAACAAAAGCTCTCAGCAAAAAAGGAAACAAATCGTTT
GAAGAAATACTCAGGGTCGGCACGTCTGCGGGCGGCGCTCGTGCAAAAATCCTTGTGGCCTACGATGAGGAAAGTGGTGA
AATGCATTCAGGGCAAGTGGCGACCGATCCGAGATTTGGCTATTGGCTTTTGAAACTTGACGACGTTACAAACAACCGCG
ACAAAGAAAGTGCAGACTTGTTCGGCTACGGAGCTATTGAATATTCTTATTCGCAAATGGCAAAACTTGCGGGTATTGAA
ATGACAGAATGCCGACTCTACGAATGTGCGGGCCATAGGCATTTTATGACGAGACGTTTTGACCGTCTAGCGGGCGGAAA
GAAATTGCATTACCAGTCGCTTTGCGGCATCGCCCATTACGATTTCAACATGCCGGGAGCATACAGTTACGAACAGGCGC
TAAATGTAATCAAGCGACTTGAACTCGGTTATGACGCGCTTGAAGAAATGTATCGCCGAGCTGCATTCAATATCTGCGCA
CGCAACCAAGACGACCACGCCAAAAATATCGGTTTCTTGATGGACAAGCGCGGTGTGTGGACTTTAGCGCCCGCATTTGA
CATGACGTACGCCTACAATCCACAAGGGACATGGACTGGGACGCACCAGATGACGTTCAACGGAAAGCGTAGCGGGTTTA
AGCTAGACGACTTCAAAGCTGTAGCCAAGTTTGCGGGATTGAAGCAAGGACGTTACAAGAAAATTCTTGCTGAAGTTGAA
GACGCCGTAATGCAATGGAAAAAGCTCGCCAAGCAAAACGGAGTGCCGATAAGGATCGCTCGGGCGATTGCCGGAGTACA
TGAATTTATTTTGTAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15416.41 Da
• Isoelectric Point: 9.5262

>AT24379 WP_014546447.1 NC_013410:c2183721-2183305 [Fibrobacter succinogenes subsp. succinogenes S85]
MNAYSAQTDESALTLLGKRLAAFRIRNNWTQAQLAEQSGVSKGTVERIERGDSVQVVNFIKVLRACGMLESFLSIFPDDS
PSPMQLLYMGKIKSRQRVRSPHKNTNTANILADNAAEYNADKPANDASKTPWVWNEDK

Nucleotide

• Length: 417 bp

>AT24379 NC_013410:c2183721-2183305 [Fibrobacter succinogenes subsp. succinogenes S85]
ATGAACGCATACTCCGCACAGACTGATGAATCTGCACTCACGCTACTCGGGAAACGTTTGGCAGCATTCCGCATTCGGAA
CAACTGGACACAAGCGCAACTTGCCGAACAGTCGGGAGTGAGCAAGGGAACCGTTGAGCGCATCGAGCGTGGCGATTCTG
TACAGGTTGTAAATTTCATCAAGGTACTACGTGCATGCGGGATGCTTGAAAGCTTTTTAAGCATTTTCCCCGACGATTCG
CCCTCCCCCATGCAGCTTTTATATATGGGAAAAATCAAGAGCCGCCAACGAGTCCGCAGCCCGCATAAAAACACAAACAC
AGCAAACATTTTAGCGGACAACGCCGCCGAATACAACGCAGACAAACCAGCCAACGATGCTTCCAAAACACCCTGGGTTT
GGAACGAAGACAAGTAA

Structures

Toxin

• AlphaFold DB: C9RS34