Detailed information of TA system TA243789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0299-vapB/-
• Location: 364342..364913
• Replicon: chromosome
• Accession: NZ_CP096844
• Organism: Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: M1776_RS01590
• Protein ID: WP_003401560.1
• Coordinates: 364342..364644 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: O07227
• Locus tag: M1776_RS01595
• Protein ID: WP_003401563.1
• Coordinates: 364692..364913 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1776_RS01570 (M1776_01570)	359766..360569	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
M1776_RS01575 (M1776_01575)	360579..361976	-	1398	WP_003401544.1	sulfatase	-
M1776_RS01580 (M1776_01580)	362155..363975	+	1821	WP_003401546.1	PE family protein	-
M1776_RS01585 (M1776_01585)	364118..364345	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	-
M1776_RS01590 (M1776_01590)	364342..364644	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
M1776_RS01595 (M1776_01595)	364692..364913	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	Antitoxin
M1776_RS01600 (M1776_01600)	364910..365335	+	426	WP_003401566.1	PIN domain nuclease	-
M1776_RS01605 (M1776_01605)	365471..366103	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
M1776_RS01610 (M1776_01610)	366100..367008	+	909	WP_003900117.1	protochlorophyllide reductase	-
M1776_RS01615 (M1776_01615)	367016..367606	-	591	WP_234712434.1	hypothetical protein	-
M1776_RS01620 (M1776_01620)	367599..367649	-	51	Protein_320	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (9-37)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T243789 WP_003401560.1 NZ_CP096844:364342-364644 [Mycobacterium tuberculosis variant bovis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T243789 NZ_OX637959:291052-291579 [Escherichia coli O25b:H4-ST131]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8088.31 Da
• Isoelectric Point: 10.7177

>AT243789 WP_003401563.1 NZ_CP096844:364692-364913 [Mycobacterium tuberculosis variant bovis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Nucleotide

• Length: 222 bp

>AT243789 NZ_OX637959:290779-291045 [Escherichia coli O25b:H4-ST131]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A829CG48