Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3745523..3746190 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag M1781_RS17580 Protein ID WP_003417916.1
Coordinates 3745523..3745915 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag M1781_RS17585 Protein ID WP_003912214.1
Coordinates 3745915..3746190 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS17565 (M1781_17570) 3740893..3742731 - 1839 WP_023349617.1 1-deoxy-D-xylulose-5-phosphate synthase -
M1781_RS17570 (M1781_17575) 3742728..3743717 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
M1781_RS17575 (M1781_17580) 3743717..3744769 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
M1781_RS17580 (M1781_17585) 3745523..3745915 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS17585 (M1781_17590) 3745915..3746190 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1781_RS17590 (M1781_17595) 3746372..3747743 + 1372 Protein_3474 ISNCY family transposase -
M1781_RS17595 (M1781_17600) 3747933..3750185 + 2253 WP_011799349.1 PE family protein -
M1781_RS17600 (M1781_17605) 3750256..3751128 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3747066..3747743 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T243785 WP_003417916.1 NZ_CP096843:c3745915-3745523 [Mycobacterium tuberculosis variant bovis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T243785 NZ_OX595791:c249505-249170 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT243785 WP_003912214.1 NZ_CP096843:c3746190-3745915 [Mycobacterium tuberculosis variant bovis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT243785 NZ_OX595791:c249782-249495 [Streptococcus agalactiae]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References