Detailed information of TA system TA243780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3129645..3130193
• Replicon: chromosome
• Accession: NZ_CP096843
• Organism: Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M1781_RS14870
• Protein ID: WP_079293446.1
• Coordinates: 3129930..3130193 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: O33347
• Locus tag: M1781_RS14865
• Protein ID: WP_003414599.1
• Coordinates: 3129645..3129926 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1781_RS14840 (M1781_14845)	3125268..3126125	-	858	WP_003899513.1	type I methionyl aminopeptidase	-
M1781_RS14845 (M1781_14850)	3126167..3126751	-	585	WP_010950792.1	DUF1707 domain-containing protein	-
M1781_RS14850 (M1781_14855)	3126855..3127103	+	249	WP_003913411.1	antitoxin VapB23	-
M1781_RS14855 (M1781_14860)	3127100..3127480	+	381	WP_003414592.1	type II toxin-antitoxin system VapC family toxin	-
M1781_RS14860 (M1781_14865)	3127562..3129373	-	1812	WP_003414596.1	penicillin-binding protein	-
M1781_RS14865 (M1781_14870)	3129645..3129926	+	282	WP_003414599.1	type II toxin-antitoxin system antitoxin RelF	Antitoxin
M1781_RS14870 (M1781_14875)	3129930..3130193	+	264	WP_079293446.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1781_RS14875 (M1781_14880)	3130566..3131420	-	855	WP_003899516.1	GNAT family N-acetyltransferase	-
M1781_RS14880 (M1781_14885)	3131476..3132639	-	1164	WP_003899517.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
M1781_RS14885 (M1781_14890)	3132656..3133870	-	1215	WP_003414610.1	zinc metalloprotease Rip	-
M1781_RS14890 (M1781_14895)	3133878..3135119	-	1242	WP_003414613.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10216.88 Da
• Isoelectric Point: 11.5078

>T243780 WP_079293446.1 NZ_CP096843:3129930-3130193 [Mycobacterium tuberculosis variant bovis]
VPYIVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Nucleotide

• Length: 264 bp

>T243780 NZ_CP096843:3129930-3130193 [Mycobacterium tuberculosis variant bovis]
GTGCCTTACATCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10183.40 Da
• Isoelectric Point: 4.3440

>AT243780 WP_003414599.1 NZ_CP096843:3129645-3129926 [Mycobacterium tuberculosis variant bovis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Nucleotide

• Length: 282 bp

>AT243780 NZ_CP096843:3129645-3129926 [Mycobacterium tuberculosis variant bovis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Structures

Antitoxin

• PDB: 3G5O
• AlphaFold DB: A0A7U4BWP8