Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3088800..3089404 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag M1781_RS14670 Protein ID WP_003414492.1
Coordinates 3088800..3089192 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag M1781_RS14675 Protein ID WP_003414495.1
Coordinates 3089189..3089404 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS14640 (M1781_14650) 3083950..3084738 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
M1781_RS14645 (M1781_14655) 3085072..3085617 - 546 WP_003904931.1 DUF1802 family protein -
M1781_RS14650 (M1781_14660) 3085889..3086773 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
M1781_RS14655 (M1781_14665) 3086776..3087663 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
M1781_RS14660 (M1781_14670) 3087968..3088513 - 546 WP_003899500.1 DUF1802 family protein -
M1781_RS14665 (M1781_14675) 3088510..3088779 - 270 WP_003414489.1 DUF2277 family protein -
M1781_RS14670 (M1781_14680) 3088800..3089192 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS14675 (M1781_14685) 3089189..3089404 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1781_RS14680 (M1781_14690) 3089451..3090200 + 750 WP_003414497.1 enoyl-CoA hydratase -
M1781_RS14685 (M1781_14695) 3090279..3091361 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
M1781_RS14690 (M1781_14700) 3091354..3092664 - 1311 WP_031702645.1 ABC transporter substrate-binding protein -
M1781_RS14695 (M1781_14705) 3092667..3093494 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
M1781_RS14700 (M1781_14710) 3093491..3094402 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T243779 WP_003414492.1 NZ_CP096843:c3089192-3088800 [Mycobacterium tuberculosis variant bovis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T243779 NZ_OX461117:c4316641-4315340 [Shewanella baltica]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATTATCGGGGAGTTATCCTTTGATGCGATGAC
CGACACCTTTGCCGTACATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGGAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGTGCAATTGGTCTCGATACCGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGTTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTTGCGGGTGTGCAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGCCATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCGGGGCGTGATGTTAAAGATATTCG
AGAAGGGGTAAGTTTTAACAGGCTATTTAGTCTTGCCGCAAAATGCCGTAATCCAGTGGCCGCTAAGCAGGATATGTTGC
AATGGGTGCTGTTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTATTCGTTTTTTATGACGGCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCAATTGA
TGACGAATTTGATCCAAACAGCATTTTCGCGTATCAATTGGCCGCATTTATTGATGGCTTAGGTTTACCAAGAAATCTAT
TAATCAGTAACTTAACGACAATAGCGCGAAGAATACCGCAGGCAATAGATGGTGTGATTTCAATGCTCCCGCCCCTCGAT
GAGAATGAAACATCATTTGTGGCTCATTACAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACCTTAGTTTTGCCGCCGA
GGTCAGGGATGTCGAAGTGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT243779 WP_003414495.1 NZ_CP096843:c3089404-3089189 [Mycobacterium tuberculosis variant bovis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT243779 NZ_OX461117:c4316881-4316645 [Shewanella baltica]
ATGGCATCACGGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCAGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGAGATCGTTTCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References