Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3062391..3062961 | Replicon | chromosome |
| Accession | NZ_CP096843 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb3602 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | P71650 |
| Locus tag | M1781_RS14525 | Protein ID | WP_003414166.1 |
| Coordinates | 3062391..3062747 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL61 |
| Locus tag | M1781_RS14530 | Protein ID | WP_003901465.1 |
| Coordinates | 3062731..3062961 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1781_RS14505 (M1781_14515) | 3057843..3059531 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
| M1781_RS14510 (M1781_14520) | 3059535..3059861 | - | 327 | WP_003414157.1 | hypothetical protein | - |
| M1781_RS14515 (M1781_14525) | 3060034..3060621 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
| M1781_RS14520 (M1781_14530) | 3060640..3062289 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
| M1781_RS14525 (M1781_14535) | 3062391..3062747 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
| M1781_RS14530 (M1781_14540) | 3062731..3062961 | - | 231 | WP_003901465.1 | type II toxin-antitoxin system antitoxin MazE9 | Antitoxin |
| M1781_RS14535 (M1781_14545) | 3063004..3064047 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
| M1781_RS14540 (M1781_14550) | 3064046..3064513 | + | 468 | WP_003414177.1 | DUF1778 domain-containing protein | - |
| M1781_RS14545 (M1781_14555) | 3064689..3064943 | - | 255 | WP_003917684.1 | hypothetical protein | - |
| M1781_RS14550 (M1781_14560) | 3065091..3065495 | + | 405 | WP_003414181.1 | hypothetical protein | - |
| M1781_RS14555 (M1781_14565) | 3065492..3065683 | + | 192 | WP_003414184.1 | hypothetical protein | - |
| M1781_RS14560 (M1781_14570) | 3065900..3066160 | + | 261 | Protein_2873 | transposase | - |
| M1781_RS14565 (M1781_14575) | 3067270..3067527 | + | 258 | WP_003899489.1 | hypothetical protein | - |
| M1781_RS14570 (M1781_14580) | 3067632..3067943 | + | 312 | WP_010950777.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T243777 WP_003414166.1 NZ_CP096843:c3062747-3062391 [Mycobacterium tuberculosis variant bovis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T243777 NZ_OX461117:c1673380-1673126 [Shewanella baltica]
ATGAACAAAAAACATTTAAGAACGTTGACGGCTATCTTTGCTAGGCCTGTCAGCGGAGCTATCAAGTGGTCTGATATTGA
AGCGCTGTTTATTGCTCTAGGGGCTGACATTGAAGAGCGTGAGGGGTCTCGAATTGGTGTGGTGCTGTTTGGTGAAGTTC
AGGTATATCACCGCCCACATCCTCAGAAAGAAACTGACAAAGACGCAGTGATAAGCATCAAAAAATGGTTAGAAAGGAAC
GGGGTGAAAGCATGA
ATGAACAAAAAACATTTAAGAACGTTGACGGCTATCTTTGCTAGGCCTGTCAGCGGAGCTATCAAGTGGTCTGATATTGA
AGCGCTGTTTATTGCTCTAGGGGCTGACATTGAAGAGCGTGAGGGGTCTCGAATTGGTGTGGTGCTGTTTGGTGAAGTTC
AGGTATATCACCGCCCACATCCTCAGAAAGAAACTGACAAAGACGCAGTGATAAGCATCAAAAAATGGTTAGAAAGGAAC
GGGGTGAAAGCATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT243777 WP_003901465.1 NZ_CP096843:c3062961-3062731 [Mycobacterium tuberculosis variant bovis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT243777 NZ_OX461117:c1673129-1672788 [Shewanella baltica]
ATGAAAAATCTTATGATGATCAACGGGGTAAAAGCCTTTATTGATTATGATCCAGACGCTGAAACATTCCGTGGTGAGTT
CGTAGGCTTAAACGGCGGCGCGGATTTCTATGGTGAAAGCGTCGCTCAATTGGAAGCCGAGGGCGCGAAGTCATTAACCG
TTTTTTTAGAGATGTGTCAGGAGCGTGGCATTGAGCCTTACAAAAACTTCTCTGGCAAATTCAACGTTCGGATCTCGCCA
GACGTTCACGCTCGACTTAATGAAATTGCGCTATCGCAAAGCATTAGTTTGAATGCAGCGGTAGAAAATGCAGTCAATGA
CTACATTGCACATTCAGCGTAG
ATGAAAAATCTTATGATGATCAACGGGGTAAAAGCCTTTATTGATTATGATCCAGACGCTGAAACATTCCGTGGTGAGTT
CGTAGGCTTAAACGGCGGCGCGGATTTCTATGGTGAAAGCGTCGCTCAATTGGAAGCCGAGGGCGCGAAGTCATTAACCG
TTTTTTTAGAGATGTGTCAGGAGCGTGGCATTGAGCCTTACAAAAACTTCTCTGGCAAATTCAACGTTCGGATCTCGCCA
GACGTTCACGCTCGACTTAATGAAATTGCGCTATCGCAAAGCATTAGTTTGAATGCAGCGGTAGAAAATGCAGTCAATGA
CTACATTGCACATTCAGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|