Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3022395..3023074 | Replicon | chromosome |
| Accession | NZ_CP096843 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb3602 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | M1781_RS14295 | Protein ID | WP_003414059.1 |
| Coordinates | 3022395..3022811 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | M1781_RS14300 | Protein ID | WP_003414061.1 |
| Coordinates | 3022808..3023074 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1781_RS14275 (M1781_14280) | 3018447..3019349 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| M1781_RS14280 (M1781_14285) | 3019418..3020170 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| M1781_RS14285 (M1781_14295) | 3020414..3020689 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| M1781_RS14290 (M1781_14300) | 3020686..3022308 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| M1781_RS14295 (M1781_14305) | 3022395..3022811 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| M1781_RS14300 (M1781_14310) | 3022808..3023074 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| M1781_RS14305 (M1781_14315) | 3023100..3023495 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1781_RS14310 (M1781_14320) | 3023492..3023761 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| M1781_RS14315 (M1781_14325) | 3023771..3024865 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| M1781_RS14320 (M1781_14330) | 3024862..3025281 | - | 420 | Protein_2825 | winged helix-turn-helix domain-containing protein | - |
| M1781_RS14325 (M1781_14335) | 3025280..3025354 | + | 75 | Protein_2826 | hypothetical protein | - |
| M1781_RS14330 (M1781_14340) | 3025355..3025834 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| M1781_RS14335 (M1781_14345) | 3025905..3026705 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| M1781_RS14340 (M1781_14350) | 3026861..3027598 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T243775 WP_003414059.1 NZ_CP096843:c3022811-3022395 [Mycobacterium tuberculosis variant bovis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T243775 NZ_OX461106:38531-38842 [Serratia proteamaculans]
GTGCATGTAATTAGCAGACAGCCGTTTAACGAGGCTGCCGGTAAATACCCTAATAGCGCATTGGCGCTTCTGGATTTGAT
GCGGGTTCTGGAAAAAAAGACCTTCAACAGCCCGGATGAAATGAAAAGAGCGATCCCGTCACTGGATAACTTCAAGTACC
GTAAAAAGTGGTGGGTTATCGATGTGTCCGGCAATACGCTGCGGCTTATGGCCTTCATTGACTTTGAAAAACAAAAGGTT
TTTGTTAAGCACATTGCGACTCATGCCGAATACGACAAGTTAACCAAGTATTATAGGGAGCATAAAGAATGA
GTGCATGTAATTAGCAGACAGCCGTTTAACGAGGCTGCCGGTAAATACCCTAATAGCGCATTGGCGCTTCTGGATTTGAT
GCGGGTTCTGGAAAAAAAGACCTTCAACAGCCCGGATGAAATGAAAAGAGCGATCCCGTCACTGGATAACTTCAAGTACC
GTAAAAAGTGGTGGGTTATCGATGTGTCCGGCAATACGCTGCGGCTTATGGCCTTCATTGACTTTGAAAAACAAAAGGTT
TTTGTTAAGCACATTGCGACTCATGCCGAATACGACAAGTTAACCAAGTATTATAGGGAGCATAAAGAATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT243775 WP_003414061.1 NZ_CP096843:c3023074-3022808 [Mycobacterium tuberculosis variant bovis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT243775 NZ_OX461106:38839-39282 [Serratia proteamaculans]
ATGACTGTTGCCACTCATATCGACGCCGCCAGTGCCGAAGGCATGATCGCGACATTTGCCAACGCGGTGAAATGCATTCC
TCTGATGACGGGTGATAAAAGCGAGGCTGAATACAAAAAAGCGCTTGAGCTGATTGAGTATCTTGTCGATCGCGACGAGC
TGAGCAACCCGCTTTTTGAACCGCTTGCGGCCAAAATTACAGAGTATGAAAACAGCGCCCCGGAATTTGAGGCGTTTAAC
CGCCGCTTGGCGGAGATCCCTACCGGGGTCGCCGCGTTGCGTACCCTGATGGATCAGCATGGTTTGAAAGCGGCTGATCT
GGAAGATGAATTGGGGTCTAAAAGTAATGTCAGTAACATTCTCAGTGGTCGCCGTGCGTTGACTGTGCAGCACATTAAGG
CGCTGGCGACGCGTTTTGATGTCCCTGCTGATTTGTTTATCTGA
ATGACTGTTGCCACTCATATCGACGCCGCCAGTGCCGAAGGCATGATCGCGACATTTGCCAACGCGGTGAAATGCATTCC
TCTGATGACGGGTGATAAAAGCGAGGCTGAATACAAAAAAGCGCTTGAGCTGATTGAGTATCTTGTCGATCGCGACGAGC
TGAGCAACCCGCTTTTTGAACCGCTTGCGGCCAAAATTACAGAGTATGAAAACAGCGCCCCGGAATTTGAGGCGTTTAAC
CGCCGCTTGGCGGAGATCCCTACCGGGGTCGCCGCGTTGCGTACCCTGATGGATCAGCATGGTTTGAAAGCGGCTGATCT
GGAAGATGAATTGGGGTCTAAAAGTAATGTCAGTAACATTCTCAGTGGTCGCCGTGCGTTGACTGTGCAGCACATTAAGG
CGCTGGCGACGCGTTTTGATGTCCCTGCTGATTTGTTTATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|