Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2893410..2894124 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag M1781_RS13545 Protein ID WP_003413460.1
Coordinates 2893684..2894124 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag M1781_RS13540 Protein ID WP_003413456.1
Coordinates 2893410..2893697 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS13505 (M1781_13510) 2888832..2889077 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
M1781_RS13510 (M1781_13515) 2889074..2889478 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
M1781_RS13515 (M1781_13520) 2889695..2890315 + 621 WP_003413441.1 DUF4178 domain-containing protein -
M1781_RS13520 (M1781_13525) 2890326..2890820 + 495 WP_003413444.1 DUF2617 family protein -
M1781_RS13525 (M1781_13530) 2890817..2891248 + 432 WP_003413445.1 DUF4247 domain-containing protein -
M1781_RS13530 (M1781_13535) 2891273..2891731 + 459 WP_003413451.1 DUF350 domain-containing protein -
M1781_RS13535 (M1781_13540) 2891728..2893299 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
M1781_RS13540 (M1781_13545) 2893410..2893697 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
M1781_RS13545 (M1781_13550) 2893684..2894124 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS13550 (M1781_13555) 2894145..2894900 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
M1781_RS13555 (M1781_13560) 2895033..2895629 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
M1781_RS13560 (M1781_13565) 2895637..2896482 - 846 WP_010950749.1 acyl-CoA thioesterase II -
M1781_RS13565 (M1781_13570) 2896511..2897410 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
M1781_RS13570 (M1781_13575) 2897538..2898212 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T243774 WP_003413460.1 NZ_CP096843:2893684-2894124 [Mycobacterium tuberculosis variant bovis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T243774 NZ_OX461106:4279-4611 [Serratia proteamaculans]
ATGGTTTCACGTTACGTACCAAATTCTGCTGATCTAATCTGGCTGGATTTTGACCCCGTAGAAGGTCACGAACAGGGAGG
CCATCGCCCTGCGGTCGTCCTTAGTCCTTTTTCTTACAATAATCCCGTAGGGTTGCTGCTTTGCGTTCCGTGTACCACTA
AAGCTAAAGGCTATCCATTTGAGGTTGAACTATCGGGTAGCCGCGAAAGTGTTGCTCTTGCCGATCAAGTTACCTGTGTT
GACTGGAGAGCGCGAAAAGTAACAAAGAAAGGCGCAGTATCGCCTGAAGAACTTGCTGAGATCAGAGCAAAGGCTAAGGC
TCTAATCGGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT243774 WP_003413456.1 NZ_CP096843:2893410-2893697 [Mycobacterium tuberculosis variant bovis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT243774 NZ_OX461106:4030-4278 [Serratia proteamaculans]
ATGACAACAGTAACGCTAAAAAAATGGGGCAATAGCCCATCGATCAGAATACCAGCCAGCGTAATGCAAGCAGCAGCACT
TAATGTCGAAGATAAACTCGATTTGAAAATTGATGAAGCTGGCCAAATTGTTTTAGTACCATTGAAATCTAAAGAGTATT
CACTGGATGTACTGTTATCAGGTATCACACCAGATAACGTTCACGGAAAAATAGATTTTGGTTCGCCAGTTGGAAAGGAA
TTGATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References