Detailed information of TA system TA243770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2816947..2817587
• Replicon: chromosome
• Accession: NZ_CP096843
• Organism: Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: M1781_RS13170
• Protein ID: WP_003412970.1
• Coordinates: 2816947..2817366 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: M1781_RS13175
• Protein ID: WP_003412975.1
• Coordinates: 2817363..2817587 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1781_RS13140 (M1781_13145)	2812532..2813254	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
M1781_RS13145 (M1781_13150)	2813771..2813998	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
M1781_RS13150 (M1781_13155)	2813995..2814396	+	402	WP_003412963.1	PIN domain-containing protein	-
M1781_RS13155 (M1781_13160)	2814431..2815351	-	921	WP_003412965.1	restriction endonuclease	-
M1781_RS13160 (M1781_13165)	2815692..2815898	-	207	WP_234712436.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
M1781_RS13165 (M1781_13170)	2815996..2816946	+	951	WP_003911916.1	ERCC4 domain-containing protein	-
M1781_RS13170 (M1781_13175)	2816947..2817366	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
M1781_RS13175 (M1781_13180)	2817363..2817587	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
M1781_RS13180 (M1781_13185)	2817618..2820461	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
M1781_RS13185 (M1781_13190)	2820533..2820934	-	402	WP_003412981.1	hypothetical protein	-
M1781_RS13190 (M1781_13195)	2820934..2821404	-	471	WP_003412985.1	transcription antitermination factor NusB	-
M1781_RS13195 (M1781_13200)	2821407..2821970	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T243770 WP_003412970.1 NZ_CP096843:c2817366-2816947 [Mycobacterium tuberculosis variant bovis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T243770 NZ_OX461105:c4021952-4021566 [Serratia proteamaculans]
ATGTACATGTTTGATACCAATACGGTCAGCCAACTGTTCCGTCGGCATCCCCGCTTATTGCGCGTAATGGAAAAGATCCC
GCCGTCTGCGGTCTGCATTTCCAGTATCACGGAGGCGGAATTGTTGTATGGCGTAGCCAAGCGGCAAAGTTTGGCGCTAA
AAGCGACCGTGGCGGCATTCCTGGATTCCGTGACGGTGTATGCCTGGGACCGGGAAGCCGCGCATTGCTACGGAACGATG
CGGGCGGATATGGCGAAAAAGGGGCGAGTAATGGGGGCTTTGGATCAGCTTATTGCCGCACACGCGCAGAGCCGTGGTGC
GACAATAGTGACTAACGATAAGGCGTTCGCCATGGTGCCGGGGCTGAGGGTCGAAGACTGGACCTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT243770 WP_003412975.1 NZ_CP096843:c2817587-2817363 [Mycobacterium tuberculosis variant bovis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT243770 NZ_OX461105:c4022218-4021955 [Serratia proteamaculans]
ATGGAAAGAGTCGCGAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGATTACCCGTGGAATTCGAATTTGATACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCAAAGTATCCGGCAAAACCTGACAGTTGGGCTCCAC
TGCTGCAAATGATCGAGCAAACTCAGGTGCCGCAGGACTTCCTGGTGGCTGAGGATCGTCAACAGGGGATCGCCATCCGC
GATCCGTTCGGCGAGGAAGAGTAA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09