Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2770763..2771415 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag M1781_RS12975 Protein ID WP_003412752.1
Coordinates 2770990..2771415 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag M1781_RS12970 Protein ID WP_003412749.1
Coordinates 2770763..2770984 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS12955 (M1781_12960) 2769003..2769209 - 207 WP_003899347.1 hypothetical protein -
M1781_RS12960 (M1781_12965) 2769345..2769968 + 624 WP_079293695.1 TIGR00725 family protein -
M1781_RS12965 (M1781_12970) 2769958..2770710 + 753 WP_003901416.1 hypothetical protein -
M1781_RS12970 (M1781_12975) 2770763..2770984 + 222 WP_003412749.1 antitoxin Antitoxin
M1781_RS12975 (M1781_12980) 2770990..2771415 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS12980 (M1781_12985) 2771438..2772619 - 1182 WP_010950729.1 dihydrolipoamide acetyltransferase family protein -
M1781_RS12985 (M1781_12990) 2772616..2773662 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
M1781_RS12990 (M1781_12995) 2773673..2774776 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
M1781_RS12995 (M1781_13000) 2775035..2775856 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
M1781_RS13000 (M1781_13005) 2775853..2776410 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T243769 WP_003412752.1 NZ_CP096843:2770990-2771415 [Mycobacterium tuberculosis variant bovis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T243769 NZ_OX461105:c3988139-3987870 [Serratia proteamaculans]
ATGCGGATAGAATGGAGCAGTGAGGCTCAGGAAGAGCTATGGAGCATTATTGATTATATCGATGACAGAAACCCGCAGGC
GGCGCGAAAATTGCACCGGGAAATCGAAGCGGTGGTCCTTACCCTGCCGTTAAACCCTTTAATGCACCGCTTGGGTAGGG
TGGATAATACGCGAGAAATTGTCGTCCATCCCAACTATCTGGTTGTTTATAGAGTCATCGGACATATAGAAGTTCTGAGT
GTTATTCATGCCAAACGTGAATATCCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT243769 WP_003412749.1 NZ_CP096843:2770763-2770984 [Mycobacterium tuberculosis variant bovis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT243769 NZ_OX461105:c3988337-3988143 [Serratia proteamaculans]
ATGGCGATAAAACCTCCACTCTCCACTTTGCCGGTGCTGGGCTCGGCTGAGCAAACAGAGAGTTACGATCGTTGGTACCG
GGCCAAGGTTGAGAGCGCAATTAACAGTGAACAACCGAGAATTTCACACGAACAAGTGATGACTGAAATGCAAACTCGTC
TAGCGGCAAAGAAAAAATTGCGCAAAATGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References