Detailed information of TA system TA243768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2378777..2379306
• Replicon: chromosome
• Accession: NZ_CP096843
• Organism: Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: M1781_RS11120
• Protein ID: WP_003411124.1
• Coordinates: 2378777..2379094 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: M1781_RS11125
• Protein ID: WP_003411127.1
• Coordinates: 2379091..2379306 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1781_RS11090 (M1781_11100)	2373798..2374874	+	1077	WP_003411110.1	hypothetical protein	-
M1781_RS11095 (M1781_11105)	2374871..2375152	+	282	WP_003411112.1	DUF5703 family protein	-
M1781_RS11100 (M1781_11110)	2375188..2376261	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
M1781_RS11105 (M1781_11115)	2376266..2376796	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
M1781_RS11110 (M1781_11120)	2376844..2378190	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
M1781_RS11120 (M1781_11130)	2378777..2379094	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1781_RS11125 (M1781_11135)	2379091..2379306	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
M1781_RS11130 (M1781_11140)	2379561..2380619	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
M1781_RS11135 (M1781_11145)	2380749..2381105	-	357	WP_003411130.1	hypothetical protein	-
M1781_RS11140 (M1781_11150)	2381200..2381982	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
M1781_RS11145 (M1781_11155)	2382250..2382540	-	291	WP_003900476.1	YggT family protein	-
M1781_RS11150 (M1781_11160)	2382702..2383358	-	657	WP_003411133.1	cell division protein SepF	-
M1781_RS11155 (M1781_11165)	2383424..2384200	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T243768 WP_003411124.1 NZ_CP096843:c2379094-2378777 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T243768 NZ_OX461105:c3563755-3563423 [Serratia proteamaculans]
ATGAACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCCGGCCACGAGCAAAGTGGGAAACGTCCGGTACTCAT
CGTATCGACGGCATCGTTTAACAAGCTGACCCGGCTACCTGTTGTTGTTCCGGTCACCAGCGGCGGAAACTTCGCTCGCA
CAGCTGGTTTTACTGTCTCATTGGAAGGGGCAGGAGTCAAAACAACGGGCGTTATTCGCTGCGATCAGCCCAGGACTATT
GATATGGGAGCTCGTAACGGCAGACGGCTGGAATGTATACCTAATAATGTTGTGAATGAGGTGCTGGCCAGACTGGAAGC
TATTCTGACCTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT243768 WP_003411127.1 NZ_CP096843:c2379306-2379091 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT243768 NZ_OX461105:c3564013-3563756 [Serratia proteamaculans]
ATGTATATTACTCGACTGAAAAAGGTTGGAGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGCGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCGTTATTCGC
TTGAGGAACTGCTGGCTCAATGCGATCCGCACGCCGAAATGAGCGAAGATGATCGGGAATGGATTAATGCGCCTGCAGTG
GGCAAGGAGATCCTGTAA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4