Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2341997..2342692 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag M1781_RS10915 Protein ID WP_003410811.1
Coordinates 2341997..2342431 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag M1781_RS10920 Protein ID WP_003410814.1
Coordinates 2342438..2342692 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS10905 (M1781_10915) 2338151..2341192 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
M1781_RS10910 (M1781_10920) 2341185..2342018 + 834 WP_003899172.1 SWIM zinc finger family protein -
M1781_RS10915 (M1781_10925) 2341997..2342431 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
M1781_RS10920 (M1781_10930) 2342438..2342692 - 255 WP_003410814.1 antitoxin Antitoxin
M1781_RS10925 (M1781_10935) 2342708..2342965 - 258 WP_003410816.1 hypothetical protein -
M1781_RS10930 (M1781_10940) 2343912..2344208 + 297 WP_003410820.1 PE family protein -
M1781_RS10935 (M1781_10945) 2344264..2344995 + 732 WP_003900467.1 PPE family protein -
M1781_RS10940 (M1781_10950) 2345535..2346281 - 747 WP_003901330.1 proteasome subunit alpha -
M1781_RS10945 (M1781_10955) 2346278..2347153 - 876 WP_003411023.1 proteasome subunit beta -
M1781_RS10950 (M1781_10960) 2347150..2347344 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T243767 WP_003410811.1 NZ_CP096843:c2342431-2341997 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T243767 NZ_OX461105:2110478-2110574 [Serratia proteamaculans]
AACAAGCCTTGCACAAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT243767 WP_003410814.1 NZ_CP096843:c2342692-2342438 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT243767 NZ_OX461105:c2110574-2110456 [Serratia proteamaculans]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTTGTGCAAGGCTTGTTCAGCCGTGCACTTTAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References