Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2233034..2233660 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag M1781_RS10440 Protein ID WP_003410075.1
Coordinates 2233262..2233660 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1781_RS10435 Protein ID WP_019283586.1
Coordinates 2233034..2233261 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS10425 (M1781_10435) 2231073..2231417 - 345 WP_003410065.1 ferredoxin family protein -
M1781_RS10430 (M1781_10440) 2231606..2232775 - 1170 WP_003899126.1 ATP-binding protein -
M1781_RS10435 (M1781_10445) 2233034..2233261 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1781_RS10440 (M1781_10450) 2233262..2233660 + 399 WP_003410075.1 PIN domain nuclease Toxin
M1781_RS10445 (M1781_10455) 2233843..2234274 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
M1781_RS10450 (M1781_10460) 2234375..2234809 + 435 WP_003914358.1 DUF1398 domain-containing protein -
M1781_RS10455 (M1781_10465) 2235246..2235425 - 180 Protein_2066 hypothetical protein -
M1781_RS10460 (M1781_10470) 2235513..2236133 + 621 WP_003410086.1 IS110 family transposase -
M1781_RS10465 (M1781_10475) 2236087..2236677 + 591 WP_003899131.1 IS110 family transposase -
M1781_RS10470 (M1781_10480) 2236805..2238061 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T243764 WP_003410075.1 NZ_CP096843:2233262-2233660 [Mycobacterium tuberculosis variant bovis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T243764 NZ_OX461105:848670-849587 [Serratia proteamaculans]
ATGGATAAGCATTCACCCTATTATCGCCAAGTGGCGTTGCTACTCAGTACATTACCTGTCGTAGCATCAGAGCGCTGCTT
TGCACTAAAGGGTGGGACGGCGATTAACTTGTTTGTTCGCGATTTTCCACGTTTATCAGTTGATATTGATTTGGCTTACA
TTCCGCTGGAAAACAGAGATGTGGCATTGCCAAATGTTCGGGCGGCCTTGACACGTATCGCTGAAATACTGCAACAACAG
GCGGGTATTTCGGCGGTGCTACAAACGAATAACTCTGATGAAATGCGCATTGTTGTTTATTCTCAGCAGGCACAGATTAA
GATTGAAGTTTCGCCTGTCGCACGAGGCACTCTGTATCCTTCAGAAGAACGTGATGTTGTTGAAGCGGTCGAAAACGAGT
TCGGTTTTGCAACCATTCAGGTTGTATCACTTGCCGATCTCTATGGTGGCAAGCTTTGCGCTGCATTGGATAGGCAACAT
CCTCGCGATTTCTATGACGTCAAAATGCTACTCGAAACACAAGGTATTGATCGCCAAATCTTTAATGGATTTATCACCTA
TCTGCTGGGACATCCACGTCCATTATCAGAGGTACTGAACCCCCGCTGGAAAAATATCTCTGAACTGTATGCGAATGAAT
TTAACGGAATGACATTCGATATGGTTTCTCTGGAAGAACTCAATGCGATACCCGAATTAATGGTGACGGCTCTCAAAGTA
CAATTTACTCAGCGGGATTGTGATTTTCTGATGTCTTTCAAGCGCGGTGAACCGGATTGGAGCCTTGCTCCCGAAAACCA
GATTCAGTATTTACCTGCGGTGAGGTGGAAGCTCCAAAATATTGGTCGTATGCCAAAAGAGAAACACATTCAGGCGTTGG
TGAAGCTTGAGGAGACTCTTGCCGGGTGGATAGGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT243764 WP_019283586.1 NZ_CP096843:2233034-2233261 [Mycobacterium tuberculosis variant bovis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT243764 NZ_OX461105:847904-848677 [Serratia proteamaculans]
ATGTCATCAAAGTTAAACTGGCTTTTGCAGAATACGGCACCGGGATCCTTGGTTTTGCAGTCCTGGCTGACGAAAAATGG
CATCAGCCCTTCTTTGGCCAATAAGTATATGCACAGCGACTGGTTGCAAAAACTACGTGCTGGAGTATACGTGAGGAGTG
GGCGTGAGCCTCAGTGGAGTGATGCAATTCTATGCCTGCAACATCAACTTGGGGTTTCTGTACATCTGGCAGGGCTTACT
AGTCTGACCTATCAAGGACGCTCTCATTATCTTCAGTTAACGCGCCAGGTTATTTGGCTCTGTGTTGAAAATAAAGCTTC
ATTGCCAAAGTGGTTCAAAGAATTTCCCAATGTTGAGTGGCTTTTACTTTCAAATCAGAAGCTCAATATGCATGACGGAA
AATATCTGACCGAGGTAGAAATTAAGGGCGAGCGGTTGAAGGCGAGTGTGCCGGAGTTAGCGGCTTACGAGGTTGCTAAC
GCCGTTCCAGGTTCGCTTTCATTTGAGCATGCAGCAGAGCTGTTTCAGGGCCTGGTAAACCTGAGTCCACGTAAAGTCGA
AGCATTGTTGCAATCCAGTCGAGCAGTGCAAACTAACCGCCTTTATCTATTTTTGGCCGATCACTATGCTCATGCATGGG
TTAAGCGAATAGATAAAACCAACATTGATTTAGGGGCAGGAAAGCGACAGATCGTATCGGGTGGCAAGCTGGACCAAAAA
TATCAGATCACGGTTCCAGAGAGTTTTGTTAGCAAAGAGATCTCACATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References